摘要
肠道作为机体最大的免疫器官,用以维持机体健康,而肠道微生态的失衡则易使机体出现代谢紊乱、免疫低下、炎症性肠病、病毒感染甚至组织癌变等情况。而褐藻来源的多糖可作为外源性益生元,通过保护肠道屏障、激活肠道免疫、调节肠道菌群和改变代谢产物构成等方式维持肠道稳态,从而维护机体健康。本文综述了褐藻多糖的化学组成和结构表征对肠道微生态的影响及其作用机制,并提出提高多糖得率和纯度、深入研究褐藻多糖构效关系与作用机制等未来发展建议,以期为推进褐藻多糖的开发与应用提供有益参考。
Intestinal tract as the largest immune organ in a body is used to maintain the health,but the imbalance of intestinal microecology is easy to cause metabolic disorders,immunosuppression,inflammatory bowel disease,viral infection and even tissue canceration.Polysaccharides derived from brown algae can be used as exogenous prebiotics by protecting intestinal barrier,activating intestinal immunity,regulating intestinal flora and changing the composition of metabolites,so as to maintain the health of the body.In this paper,the effects of chemical composition and structural characterization of brown alga polysaccharides on intestinal microecology and mechanism of action were reviewed.Some suggestions for future development were put forward,such as improving the yield and purity of fucoidan,and further research on the structure-activity relationship and mechanism of fucoidan to provide reference for the development and application of brown alga polysaccharides.
作者
章瑾
王尚志
杨明睿
闫滨
ZHANG Jin;WANG Shangzhi;YANG Mingrui;YAN Bin(School of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)
出处
《大连海洋大学学报》
CAS
CSCD
北大核心
2024年第2期349-359,共11页
Journal of Dalian Ocean University
基金
国家“重大新药创制”科技重大专项(2014ZX09509001)。
关键词
肠道微生态
肠道屏障
肠道菌群
免疫
褐藻多糖
intestinal microecology
intestinal barrier
intestinal flora
immune
brown alga polysaccharides
