摘要
目的探讨子痫前期母亲分娩早产儿甲状腺功能的特点及其影响因素。方法选取2019年1—12月于我院新生儿重症监护病房住院的222例早产儿,根据其母亲有无子痫前期,分为试验组120例和对照组102例。收集两组早产儿及其母亲的临床基本资料,以及早产儿生后10~14 d的外周静脉血甲状腺功能检测结果。采用Student-t检验、单因素方差分析及多元逐步回归分析评价早产儿甲状腺功能的影响因素。结果两组早产儿母亲的甲状腺功能没有显著差异(P>0.05)。试验组早产儿血清促甲状腺激素(TSH)水平显著高于对照组(t=-2.76,P<0.01)。多元逐步回归分析显示,母亲的收缩压及早产儿的出生体质量是早产儿甲状腺功能的主要影响因素(F=7.370、6.334,P<0.05)。结论子痫前期母亲分娩早产儿血清TSH水平显著高于血压正常母亲分娩早产儿,早产儿血清TSH水平与母亲甲状腺功能无明显相关性。
Objective To investigate the characteristics of thyroid function and its influencing factors in preterm infants born to mothers with preeclampsia.Methods A total of 222 preterm infants,who were admitted to the neonatal intensive care unit of our hospital from January to December 2019,were enrolled,and according to the presence or absence of preeclampsia in the mother,they were divided into experimental group with 120 infants and control group with 102 infants.Basic clinical data were collected from the preterm infants and their mothers,as well as the results of thyroid function test using peripheral venous blood of preterm infants at 10-14 d after birth.The Student’s t-test,a one-way analysis of variance,and the multiple stepwise regression analysis were used to investigate the influencing factors for thyroid function in preterm infants.Results There was no significant difference in maternal thyroid function between the two groups(P>0.05).The experimental group had a significantly higher se-rum level of thyroid stimulating hormone(TSH)than the control group(t=-2.76,P<0.01).The multiple stepwise regression analysis showed that systolic pressure of the mother and birth weight of the preterm infant were the main influencing factors for thyroid function in preterm infants(F=7.370,6.334,P<0.05).Conclusion Preterm infants born to mothers with preeclampsia have a significantly higher serum level of TSH than those born to mothers with normal blood pressure,and there is no significant association between serum TSH level of preterm infants and maternal thyroid function.
作者
刘子艳
姜红
张璐璐
张沂洁
李婷
刘燕
LIU Ziyan;JIANG Hong;ZHANG Lulu;ZHANG Yijie;LI Ting;LIU Yan(Children’s Medical Center,The Affiliated Hospital of Qingdao University,Qingdao 266003,China)
出处
《精准医学杂志》
2024年第2期155-158,共4页
Journal of Precision Medicine
基金
山东省医药卫生科技发展计划项目(2016WS0267)。
关键词
子痫前期
分娩
甲状腺功能试验
影响因素分析
婴儿
早产
Pre-eclampsia
Parturition
Thyroid function tests
Root cause analysis
Infant,premature
