摘要
目的分析急诊溶栓+替奈普酶联合冠心宁治疗老年急性心肌梗死的临床效果及其安全性。方法随机选择在2020年10月—2023年6月新沂市中医医院接受经皮冠脉介入术(Percutaneous Coronary Intervention,PCI)治疗的80例老年急性心肌梗死患者为研究对象,根据单双数法分为对照组和观察组,单数为对照组(40例,常规溶栓治疗),双数为观察组(40例,常规溶栓加替奈普酶联合冠心宁治疗)。对比两组临床治疗效果、心功能指标及不良反应发生情况。结果观察组治疗总有效率为95.00%,高于对照组的77.50%,差异有统计学意义(χ^(2)=5.165,P<0.05)。治疗后,观察组左室收缩末期内径为(42.32±4.65)mm,较对照组的(45.46±4.73)mm更低,左室射血分数为(57.24±8.03)%,较对照组的(50.31±7.97)%更高,差异有统计学意义(t=2.994、3.874,P均<0.05)。两组患者的不良反应发生率对比,差异无统计学意义(P>0.05)。结论老年急性心肌梗死患者在常规溶栓治疗的基础上加用替奈普酶联合冠心宁,可进一步提高临床效果,促进患者心功能改善,且不会增加用药风险,具有较高的安全性。
Objective To analyze the clinical effect and safety of emergency thrombolysis and teneplase combined with Guanxinning in the treatment of senile acute myocardial infarction.Methods A total of 80 elderly patients with acute myocardial infarction received percutaneous coronary intervention(PCI)in Xinyi Hospital of Traditional Chinese Medicine from October 2020 to June 2023 were randomly selected as the research objects.They were divided into control group and observation group according to odd-even number method,singular number was divided into control group(40 cases,conventional thrombolytic therapy),and even number was divided into observation group(40 cases,on the basis of control group plus teneplase combined with Guanxinning treatment).The clinical therapeutic effect,cardiac function indexes and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.00%,which was higher than that of the control group 77.50%,the difference was statistically significant(χ^(2)=5.165,P<0.05).After treatment,the left ventricular end-systolic diameter in the observation group was(42.32±4.65)mm,which was lower than that in the control group[(45.46±4.73)mm],the left ventricular ejection fraction of the observation group was(57.24±8.03)%,which was higher than control group[(50.31±7.97)%],the differences were statistically significant(t=2.994,3.874,both P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Teneplase combined with Guanxinning in elderly patients with acute myocardial infarction on the basis of conventional thrombolytic therapy can further improve the clinical effect,promote patients'heart function,and do not increase the risk of medication,with high safety.
作者
许曼
刘勇
王颖
XU Man;LIU Yong;WANG Ying(Department of Emergency,Xinyi Hospital of Traditional Chinese Medicine,Xinyi,Jiangsu Province,221400 China;Department of Cardiology,Xinyi Hospital of Traditional Chinese Medicine,Xinyi,Jiangsu Province,221400 China)
出处
《中外医疗》
2024年第8期120-123,共4页
China & Foreign Medical Treatment
关键词
急诊
溶栓
老年急性心肌梗死
临床效果
安全性
Emergency treatment
Thrombolysis
Senile acute myocardial infarction
Clinical effect
Security
