摘要
目的分析妊娠高血压综合征(Hypertensive Disorder Complicating Pregnancy,HDCP)实施硝苯地平+硫酸镁治疗的安全性。方法选取2020年11月—2023年11月日照市中心医院收治的83例HDCP患者作为研究对象,按随机数表法分为普通组(n=41)、调查组(n=42)。普通组行硫酸镁治疗,调查组联合硝苯地平治疗,比较两组血压指标、子宫血流情况、肾功能,评估安全性。结果治疗后,两组舒张压和收缩压水平均下降,其中调查组(71.36±4.98)、(118.02±7.07)mmHg低于普通组,差异有统计学意义(t=8.028、6.988,P均<0.05);治疗后两组搏动指数、阻力指数以及收缩峰值流速均下降,其中调查组低于普通组,差异有统计学意义(P均<0.05);治疗后两组肌酐以及24 h尿蛋白均下降,其中调查组低于普通组,差异有统计学意义(P均<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论硝苯地平+硫酸镁具有一定的安全性,能降低血压,改善各HDCP患者子宫位置的血流情况,还能预防肾脏损伤。
Objective To analyze the safety of nifedipine+magnesium sulfate treatment for hypertensive disorder complicating pregnancy(HDCP).Methods A total of 83 cases of HDCP patients admitted to Rizhao Central Hospital from November 2020 to November 2023 were selected as the study objects.They were divided into the ordinary group(n=41)and investigation group(n=42)by random number table method.The ordinary group was treated with magne sium sulfate,and the investigation group was treated with combined nifedipine.The blood pressure indexes,uterine blood flow,and renal function were compared,and the safety was assessed between the two groups.Results After treat ment,the levels of diastolic and systolic blood pressure of two groups were decreased,the investigation group of(71.36±4.98)mmHg and(118.02±7.07)mmHg were lower than those in the ordinary group,and the differences were statistically significant(t=8.028,6.988,both P<0.05).The beating index,resistance index,and peak systolic flow rate of two groups were decreased after treatment,the investigation group was lower than the ordinary group,and the differ ences were statistically significant(both P<0.05).After treatment,creatinine and 24 h urine proteins of two groups were decreased,the investigation group was lower than the ordinary group,and the differences were statistically signifi cant(both P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Nifedipine+magnesium sulfate has a certain degree of safety,can reduce blood pressure,improve the blood flow in the uterine position of each HDCP patient,and can also prevent kidney damage.
作者
孙士芬
王慧
刘坤
SUN Shifen;WANG Hui;LIU Kun(Department of Obstetrics,Rizhao Central Hospital,Rizhao,Shandong Province,276800 China;Department of Hu man Resources,Rizhao Central Hospital,Rizhao,Shandong Province,276800 China)
出处
《系统医学》
2024年第6期165-167,171,共4页
Systems Medicine
关键词
妊娠高血压综合征
安全性
硫酸镁
子宫血流
硝苯地平
Hypertensive disorder complicating pregnancy
Safety
Magnesium sulfate
Uterine blood flow
Nifedipine
