摘要
目的:观察和阳消瘿汤联合优甲乐治疗脾气亏虚型桥本甲状腺炎的疗效及对甲状腺激素、甲状腺自身抗体水平的影响。方法:选取2020年5月~2022年5月期间于我院接受治疗的脾气亏虚型桥本甲状腺炎患者114例为研究对象,按照随机数字表法分为观察组与对照组,其中57例对照组患者给予优甲乐治疗,57例观察组患者在以上对照组基础上给予和阳消瘿汤。比较两组治疗前后甲状腺激素[游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))、促甲状腺激素(TSH)]、甲状腺自身抗体水平[抗甲状腺球蛋白抗体(TG-Ab)、甲状腺过氧化物酶抗体(TPO-Ab)]及中医证候积分的变化,并对其疗效及安全性进行客观评价。结果:治疗前两组各项指标比较无明显差异(P>0.05),治疗后TG-Ab、TPO-Ab、TSH及中医证候积分均降低(P<0.05),FT_(3)、FT_(4)均升高(P<0.05),且治疗后观察组TG-Ab、TPO-Ab、TSH、中医证候积分低于对照组(P<0.05),FT_(3)、FT_(4)高于对照组,差异有统计学意义(P<0.05);观察组总有效率为91.23%,明显高于对照组的71.93%(P<0.05),但两组不良事件发生率相比差异无统计学意义(P>0.05)。结论:和阳消瘿汤联合优甲乐治疗脾气亏虚型桥本甲状腺炎,与单纯优甲乐治疗相比,在调节甲状腺激素、降低自身抗体水平、纠正临床症状上优势明显,且疗效及安全性可靠。
Objective:To observe the effects of Heyang Xiaoying Decoction combined with Euthyrox in the treatment of Hashimoto's thyroiditis due to spleen qi deficiency and the influence on thyroid hormones and thyroid autoantibodies.Methods:A total of 114patients with Hashimoto's thyroiditis due to spleen qi deficiency who were treated in the hospital from May 2020to May 2022were selected as the study subjects.They were divided into the observation group(n=57)and the control group(n=57)by random number table method.Patients in the control group were treated with Euthyrox,and those in the observation group were treated with Heyang Xiaoying Decoction combined with Euthyrox.Changes in thyroid hormones[free triiodothyronine(FT_(3)),free thyroxine(FT_(4))and thyroid stimulating hormone(TSH)],thyroid autoantibodies[thyroglobulin antibodies(TG-Ab)and thyroid peroxidase antibody(TPO-Ab)]and TCM syndrome scores after treatment were compared between the two groups.Efficacy and safety were evaluated.Results:There was no significant difference in relevant indicators between the two groups before treatment(P>0.05).After treatment,TG-Ab,TPO-Ab,TSH and TCM syndrome scores decreased(P<0.05).FT_(3) and FT_(4) increased(P<0.05).TG-Ab,TPO-Ab,TSH and TCM syndrome scores in the observation group were lower than those in the control group(P<0.05).FT_(3) and FT_(4) were higher than those in the control group(P<0.05).The total response rate in the observation group(91.23%)was significantly higher than that in the control group(71.93%)(P<0.05),but there was no statistically significant difference in the incidence of adverse events(P>0.05).Conclusion:Heyang Xiaoying Decoction combined with Euthyrox for treating Hashimoto's thyroiditis due to spleen qi deficiency has significant advantages in regulating thyroid hormones,lowering autoantibody levels and correcting clinical symptoms.Besides,the treatment is reliable and safe.
作者
李志坚
海军
赵卫华
LI Zhijian;HAI Jun;ZHAO Weihua(Orthopaedic rehabilitation Department,Hospital of Northwestern Polytechnical University,Xi'an Shaanxi 710072,China;Hepatological Surgery Department,Shaanxi Provincial People's Hospital,Xi'an Shaanxi 710068,China)
出处
《四川中医》
2024年第2期148-152,共5页
Journal of Sichuan of Traditional Chinese Medicine
基金
陕西省重点研发计划项目一般项目-社会发展领域(编号:2022SF-117)。
关键词
和阳消瘿汤
优甲乐
脾气亏虚型
桥本甲状腺炎
疗效
甲状腺激素
甲状腺自身抗体水平
Heyang Xiaoying Decoction
Euthyrox
Spleen qi deficiency pattern
Hashimoto's thyroiditis
Efficacy
Thyroid hormone
Thyroid autoantibody level
