摘要
目的 探究自拟健脾除积方联合免疫检查点抑制剂治疗对晚期非小细胞肺癌患者的临床疗效及对其外周血管生长因子的影响。方法 选取2021年6月—2022年12月期间河北省沧州中西医结合医院收治的晚期非小细胞肺癌患者70例,按随机数字表法分为对照组和治疗组,每组各35例。对照组给予常规化疗方法,采用信迪利单抗联合含铂双药治疗,治疗组在对照组的基础上加用自拟健脾除积方治疗。每21 d(3周)为一个治疗周期,两组患者连续接受2个疗程的药物治疗,观察比较两组患者临床疗效、不良反应情况,治疗前后中医临床证候评分、KPS评分、血管生长因子(Vascular endothelial growth factor,VEGF)水平。结果 治疗后治疗组总有效率88.57%(31/35)明显高于对照组65.71%(23/35),差异有统计学意义(P<0.05)。治疗后两组患者中医证候评分均较治疗前降低,功能状态疗效KPS评分均较治疗前升高,差异有统计学意义(P<0.05);且治疗组中医证候评分明显低于对照组,功能状态疗效KPS评分明显高于对照组,差异有统计学意义(P<0.01)。治疗后两组患者血清VEGF水平均较治疗前降低,差异有统计学意义(P<0.05);且治疗组血清VEGF水平明显低于对照组,差异有统计学意义(P<0.05)。两组患者不良反应分级比较,差异无统计学意义(P>0.05)。治疗组白细胞计数降低、恶心/呕吐发生率明显低于对照组,差异有统计学意义(P<0.05)。结论 自拟健脾除积方联合免疫检查点抑制剂治疗晚期非小细胞肺可提高临床治疗效果,改善中医证候评分,提高生活质量,降低外周血血管生长因子含量,且具有相当的安全性,值得推荐使用。
Objective To investigate the clinical efficacy of self-made Jianpi Chuji Recipe in conjunction with immune checkpoint inhibitor in treating advanced non-small cell lung cancer(NSCLC)and its impact on peripheral vascular endothelial growth factor(VEGF).Methods A total of 70 patients with advanced NSCLC treated at the Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from June 2021 to December 2022 were selected and divided into a control group and a treatment group by random number table,with 35 in each group.The control group received standard chemotherapy,consisting of sintilimab and platinum-based doublet chemotherapy.The treatment group was given self-made Jianpi Chuji Recipe on the basis of the control group.Each treatment cycle was 21 days(3 weeks),and patients in both groups underwent two consecutive cycles.The clinical efficacy,adverse reactions,traditional Chinese medicine(TCM)syndrome scores,Karnofsky Performance Status(KPS)scores,and VEGF were detected and compared between groups before and after treatment.Results The total effective rate of the treatment group was 88.57%(31/35),higher than the 65.71%(23/35)of the control group(P<0.05).After treatment,TCM syndrome scores were decreased and KPS scores were increased in both groups(P<0.05),with significant improvements in the treatment group when compared with the control group(P<0.01).Serum VEGF was down-regulated in both groups after treatment(P<0.05)and it was lower in the treatment group than in the control group(P<0.05).There was no difference in the grades of adverse reactions between the two groups(P>0.05);however,rates of white blood cell count decrease and nausea/vomiting were lower in the treatment group(P<0.05).Conclusion Self-made Jianpi Chuji Recipe combined with immune checkpoint inhibitor can enhance the clinical treatment effects of advanced NSCLC,improve TCM syndrome scores,raise the quality of life,and reduce peripheral VEGF,with high safe,which is worthy of recommendation for use.
作者
李金红
蒋玥
孟雅楠
张振山
张志涛
胡志伟
刘非
LI Jin-hong;JINAG Yue;MENG Ya-nan;ZHANG Zhen-shan;ZHANG Zhi-tao;HU Zhi-wei;LIU Fei(Department of Radiology and ChemotherapyⅢ,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Cangzhou Hebei061000)
出处
《世界中西医结合杂志》
2024年第4期759-763,共5页
World Journal of Integrated Traditional and Western Medicine
基金
河北省中医药管理局科研计划课题项目(2022247)。
关键词
非小细胞肺癌晚期
自拟健脾除积方
免疫检查点抑制剂
血管生长因子
Advanced non-small cell lung cancer
Self-made Jianpi Chuji Recipe
Immune checkpoint inhibitor
Vascular endothelial growth factor
