摘要
目的 探讨自拟中药组方联合同步放化疗对晚期食管癌患者短期疗效及生存预后的影响。方法 选取2018年2月—2019年3月期间在河北省退役军人总医院接受治疗的80例晚期食管癌患者作为研究对象。采用随机数字表法分为对照组和观察组,每组各40例。两组患者均行同步放化疗治疗,观察组在对照组基础上加以自拟中药组方治疗。治疗8周后,观察比较两组患者短期疗效、中医证候积分、1年无进展生存率、血液指标及毒副作用发生情况。结果 治疗后观察组总有效率77.50%(31/40)明显高于对照组55.00%(22/40),差异有统计学意义(P<0.05)。治疗后两组患者主症、次症积分均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组主症、次症积分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者CD44及唾液酸水平均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组CD44及唾液酸水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗期间,观察组患者不同严重程度骨髓抑制、肝功能损害及恶心呕吐发生率均明显高于对照组,差异有统计学意义(P<0.05)。观察组1年无进展生存率72.50%(29/40)明显优于对照组50%(20/40),差异有统计学意义(P<0.05)。结论 自拟中药组方联合同步放化疗较单独使用同步放化疗可有效提高晚期食管癌患者临床疗效,提高1年无进展生存率,降低中医证候评分、CD44、唾液酸水平及毒副作用发生率。
Objective To explore the short-term efficacy and impact on survival prognosis of self-developed Chinese medicine prescription combined with synchronous radiochemotherapy in patients with advanced esophageal cancer.Methods A total of 80 patients with advanced esophageal cancer who were treated in Hebei General Hospital for Veterans from February 2018 to March 2019 were selected as research subjects.The patients were divided into 2 groups by random number table method,with 40 cases in each group.Both groups of patients were treated with concurrent radiotherapy and chemotherapy,and patients in the observation group were treated with self-developed Chinese medicine prescription on this basis.After 8 weeks of treatment,short-term efficacy,TCM syndrome scores,1-year progression-free survival rate,blood indicators,and toxic and side effects were compared between the two groups.Results After treatment,the total effective rate of the observation group was 77.50%(31/40),which was higher thanthat of the control group(55.00%,22/40)(P<0.05).After treatment,the scores of the primary syndrome and the secondary syndromes of the two groups of patients decreased significantly compared with those before treatment(P<0.05),and the scores in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the CD44 and sialic acid levels of the two groups of patients decreased significantly compared with those before treatment(P<0.05),and the decrease was even greater in the observation group(P<0.05).During the treatment,the incidence of bone marrow suppression,liver damage,nausea and vomiting in the observation group was higher than that in the control group(P<0.05).The 1-year progression free survival rate in the control group was 50%(20/40),which was significantly lower than that in the observation group(72.50%,29/40)(P<0.05).Conclusion The combination of self-prepared Chinese medicine prescription and synchronous radiochemotherapy can effectively improve the clinical efficacy of patients with advanced esophageal cancer,increase the 1-year progression free survival rate,and reduce the TCM syndrome score,CD44 and sialic acid levels,and the incidence of side effects compared with synchronous radiochemotherapy alone.
作者
王玉强
张永红
齐增平
乔钦增
郭秋峰
路大鹏
路洪超
WANG Yu-qiang;ZHANG Yong-hong;QI Zeng-ping;QIAO Qin-zeng;GUO Qiu-feng;LU Da-peng;LU Hong-chao(Department of Oncology,Hebei General Hospital for Veterans,Xingtai Hebei 054000;Department of Radiotherapy,Hebei General Hospital for Veterans,Xingtai Hebei 054000;Department of Medical Imaging,Hebei General Hospital for Veterans,Xingtai Hebei 054000;Department of Surgical Oncology,Hebei General Hospital for Veterans,Xingtai Hebei 054000)
出处
《世界中西医结合杂志》
2024年第4期769-773,共5页
World Journal of Integrated Traditional and Western Medicine
基金
河北省科学技术研究与发展计划项目(162777275)。
关键词
中药组方
同步放化疗
晚期食管癌
生存预后
Chinese Medicine Prescription
Synchronous Radiochemotherapy
Advanced Esophageal Cancer
Survival Prognosis
