摘要
目的探究石英毓麟汤加减对肾虚血瘀型多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者免疫调控、抗缪勒管激素(anti-mullerian hormone,AMH)、促卵泡生成素(follicle stimulating hormone,FSH)水平的影响。方法选取2021年3月—2022年3月收集的肾虚血瘀型多囊卵巢综合征患者78例,采用随机数字表法分试验组及对照组各39例,对照组给予炔雌醇环丙孕酮片,试验组在对照组的基础上予以石英毓麟汤加减。对比两组临床疗效、中医症状积分、B超检测结果、血清激素指标、外周血自然杀伤细胞(natural killer cell,NK)、外周血辅助性T淋巴细胞1(T helper cell,Th1)/辅助性T淋巴细胞2(T helper cell,Th2)及不良反应情况。结果治疗后与对照组相比,试验组临床总有效率较高(P<0.05);治疗后两组经期量少或闭经、性欲减退、头晕耳鸣、腰膝酸软、痛经且经血含血块评分降低(P<0.05),与对照组相比,试验组经期量少或闭经、性欲减退、头晕耳鸣、腰膝酸软、痛经且经血含血块较低(P<0.05);治疗后与对照组相比,试验组子宫内膜厚度、优势卵泡率均较高(P<0.05);治疗后两组促黄体生成素(Luteinizing hormone,LH)、FSH、睾酮(Testosterone,T)及AMH水平下降,雌激素(Estrogen,E2)升高(P<0.05),与对照组相比,试验组LH、FSH、T及AMH水平较低,E2较高(P<0.05);治疗后两组NK细胞、干扰素(interferon,IFN)-γ、白细胞介素-4(interleukin,IL-4)及Th1/Th2下降(P<0.05),与对照组相比,试验组NK细胞、IFN-γ、IL-4及Th1/Th2较低(P<0.05);治疗后与对照组相比,试验组不良反应总发生率较低(P<0.05)。结论石英毓麟汤加减治疗肾虚血瘀型多囊卵巢综合征患者临床效果显著,能调节患者体内NK细胞活性,纠正Th1/Th2细胞因子失衡状态,改善月经等临床症状,提高排卵率,改善激素水平。
Objective To explore the effects of Modified Shiying Yulin Decoction(石英毓麟汤加减)on immune regulation,the levels of anti-muller's tube hormone(AMH)and follicle stimulating hormone(FSH)in patients with polycystic ovary syn⁃drome(PCOS)with kidney deficiency and blood stasis.Methods A total of 78 patients with PCOS with kidney deficiency and blood stasis in the hospital from March 2021 to March 2022 were selected and divided into experimental group and control group with 39 cases in each by random number table method.The control group was given ethinylestradiol cyproterone tablets,and the experimental group was given Modified Shiying Yulin Decoction on the basis of the control group.Clinical efficacy,TCM symptom scores,B-ultrasound detection results,serum hormone indexes,peripheral blood NK cells,peripheral blood Th1/Th2 cytokines and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the experimental group was higher than that of the control group(P<0.05).After treatment,the two groups had less menstrual volume or amenor⁃rhea,decreased libido,dizziness and tinnitus,waist and knee tenderness,dysmenorrhea and decreased menstrual blood clot score(P<0.05).Compared with the control group,the experimental group had less menstrual volume or amenorrhea,decreased libi⁃do,dizziness and tinnitus,waist and knee tenderness,dysmenorrhea,and had lower menstrual blood clot content(P<0.05).Compared with those of the control group,the endometrial thickness and dominant follicle rate of the experimental group were higher after treatment(P<0.05).After treatment,the levels of luteinizing hormone(LH),FSH,testosterone(T)and AMH in the two groups were decreased,while the level of estrogen(E2)was increased(P<0.05).Compared with those of the control group,the levels of LH,FSH,T and AMH in the experimental group were lower,and the level of E2 was higher(P<0.05).After treat⁃ment,NK cells,the levels of interferon-γ(IFN-γ),interleukin-4(IL-4)and Th1/Th2 in both groups were decreased(P<0.05),and NK cells,the levels of IFN-γ,IL-4 and Th1/Th2 in the experimental group were lower than those in the control group(P<0.05).After treatment,the total incidence of adverse reactions in the experimental group was lower than that in the control group(P<0.05).Results Shiying Yulin Decoction has significant clinical effect in the treatment of PCOS with kidney de⁃ficiency and blood stasis.It can regulate the activity of NK cells in patients,correct the imbalance of Th1/Th2 cytokines,improve the condition of uterus and ovary,increase the ovulation rate and improve the hormone levels.
作者
薄晓莉
潘静
冷静
吐松古·艾买尔
韩璐
BO Xiaoli;PAN Jing;LENG Jing;TUSONGGU·AiMaiEr;HAN Lu(The Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830063,Xinjiang,China;Traditional Chinese Medicine Affiliated Hospital of Xinjiang Medical University,Urumqi 830063,Xinjiang,China)
出处
《中华中医药学刊》
CAS
北大核心
2024年第5期156-159,共4页
Chinese Archives of Traditional Chinese Medicine
基金
新疆维吾尔自治区自然科学基金项目(2020D01C187)。
关键词
石英毓麟汤加减
肾虚血瘀型多囊卵巢综合征
免疫调控
抗缪勒氏管激素(AMH)
卵泡刺激素(FSH)
Modified Shiying Yulin Decoction(石英毓麟汤加减)
Polycystic ovary syndrome with kidney deficiency and blood stasis
immune regulation
anti-muller's tube hormone(AMH)
follicle stimulating hormone(FSH)
