摘要
目的:探讨宫血宁胶囊联合雌孕激素序贯疗法治疗药物流产后阴道出血患者的效果。方法:选取2020年1月至2022年6月该院收治的90例药物流产后阴道出血患者进行前瞻性研究,按照随机数表法将其分为对照组与观察组各45例。对照组采用雌孕激素序贯疗法(口服戊酸雌二醇片+黄体酮胶囊)治疗,观察组在对照组基础上联合宫血宁胶囊治疗。比较两组临床疗效、阴道止血时间、月经恢复正常时间、治疗前后子宫内膜厚度和性激素水平,以及不良反应发生率。结果:观察组治疗总有效率为91.11%(41/45),高于对照组的71.11%(32/45),差异有统计学意义(P<0.05);观察组阴道止血时间、月经恢复正常时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组子宫内膜厚度大于对照组,雌二醇水平高于对照组,孕酮水平低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:宫血宁胶囊联合雌孕激素序贯疗法治疗药物流产后阴道出血患者可提高治疗总有效率,缩短阴道止血时间和月经恢复正常时间,促进子宫内膜修复,改善雌二醇、孕酮水平,效果优于单用雌孕激素序贯疗法。
Objective:To observe clinical effects of Gongxuening capsules combined with Estrogen and Progesterone sequential therapy on patients with vaginal bleeding after medical abortion.Methods:A prospective study was conducted on 90 patients with vaginal bleeding after medical abortion admitted to this hospital from January 2020 to June 2022.According to the random number table method,they were divided into control group and observation group,45 cases in each group.The control group was treated with Estrogen and Progesterone sequential therapy(oral Estradiol valerate tablets+Progesterone capsules),while the observation group was treated with Gongxuening capsules on the basis of that of the control group.The clinical efficacy,the vaginal hemostasis time,the menstrual recovery time,the endometrial thickness and the sex hormone levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 91.11%(41/45),which was higher than 71.11%(32/45)of the control group,and the difference was statistically significant(P<0.05).The vaginal hemostasis time and the menstrual recovery time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the endometrial thickness of the observation group was greater than that of the control group,the Estradiol level was higher than that of the control group,the progesterone level was lower than that of the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Gongxuening capsules combined with Estrogen and Progesterone sequential therapy in the treatment of vaginal bleeding after medical abortion can improve the total effective rate of treatment,shorten the vaginal hemostasis time and the menstrual recovery time,promote the endometrial repair,and improve the estradiol and progesterone levels.Moreover,it is superior to single Estrogen and Progesterone sequential therapy.
作者
王平平
WANG Pingping(Department of Obstetrics and Gynecology of Huaibin County People’s Hospital,Xinyang 464400 Henan,China)
出处
《中国民康医学》
2024年第9期82-84,共3页
Medical Journal of Chinese People’s Health
关键词
药物流产
阴道出血
宫血宁胶囊
雌孕激素序贯疗法
黄体酮
戊酸雌二醇
Medical abortion
Vaginal bleeding
Gongxuening capsules
Estrogen and Progesterone sequential therapy
Progesterone
Estradiol valerate
