摘要
目的:探讨经验性膳食炎症指数(eDⅡ)与老年冠心病患者病情及炎症状态的关系。方法:选取2021年1月—2023年1月在本院收治的老年冠心病患者45例作为病例组,选取同期30名健康体检者作为对照组。进一步依据Gensini评分评估患者病情,分为轻度组、中度组、重度组。采用酶联免疫吸附法检测IL-6、IL-10、CTP、CatK、MMP-2、MMP-9,采用双抗体夹心酶联免疫吸附试验检测TNF-α,采用免疫散射比浊法检测hs-CRP。比较不同组eDⅡ评分、炎症因子、Gensini评分,相关性分析eDⅡ与病情及炎症状态的关系。结果:病例组eDⅡ、炎症因子均高于对照组(P<0.05);3组eDⅡ、炎症因子、Gensini评分比较差异有统计学意义(P<0.05),重度组最高,中度组次之,轻度组最低;3组斑块稳定性相关指标(CTP、CatK、MMP-2、MMP-9)比较差异有统计学意义(P<0.05),重度组最高,中度组次之,轻度组最低;相关性分析显示,老年冠心病患者eDⅡ与斑块稳定性相关指标、炎症因子均呈正相关(P<0.05)。结论:高eDⅡ值与较高的炎症因子水平和Gensini评分相关,提示了膳食炎症对冠心病的发展和炎症状态的影响,通过调整饮食以降低膳食炎症指数,可能有助于改善老年冠心病患者的病情和炎症状态。
【Objective】To investigate the relationship between empirical dietary inflammation index and the disease and inflammatory state of elderly patients with coronary heart disease.【Method】Totally 45 elderly patients with coronary heart disease admitted to our hospital from January 2021 to January 2023 were selected as the case group,and 30 healthy subjects were selected as the control group dur‐ing the same period.The patients were further evaluated according to Gensini score and divided into mild group,moderate group and severe group.IL-6,IL-10,CTP,CatK,MMP-2,MMP-9 were detected by enzyme-linked immunosorbent assay(ELISA),TNF-αwas detected by dual-antibody ELISA,and hs-CRP was detected by immunoscattering turbidimetry.eDII score,inflammatory factors and Gensini score were compared among different groups,and the correlation between eDII and disease and inflammatory state was analyzed.【Result】eDII,inflammatory factors(TNF-α,hs-CRP,IL-6,IL-10)in case group were higher than those in control group(P<0.05).There were statisti‐cally significant differences in eDII,inflammatory factors(TNF-α,hs-CRP,IL-6,IL-10)and Gensini scores among the three groups in severe group(P<0.05),the highest in severe group,followed by moderate group,and the lowest in mild group.The plaque stability related indexes(CTP,CatK,MMP-2,MMP-9)of the three groups were significantly different(P<0.05),and the severe group was the highest,followed by the moderate group,and the mild group was the lowest.Correlation analysis showed that eDII was positively correlated with plaque stability and inflammatory factors in elderly patients with coronary heart disease(P<0.05).【Conclusion】High eDII value is as‐sociated with higher levels of inflammatory factors and Gensini score,suggesting the influence of dietary inflammation on the development and inflammatory status of CHD.Adjusting diet to reduce dietary inflammation index may help improve the disease and inflammatory status of elderly patients with CHD.
作者
任琳
王倩
陈皓
赵甲彧
马利祥
REN Lin;WANG Qian;CHEN Hao;ZHAO Jia-yu;MA Li-xiang(Department of Cardiology,The First Hospital of Qinhuangdao,Qinhuangdao 066000,China;Department of Geriatrics,The First Hospital of Qinhuangdao,Qinhuangdao 066000,China)
出处
《中国食物与营养》
2024年第3期78-82,共5页
Food and Nutrition in China
基金
河北省医学科学研究重点课题计划项目(项目编号:20242067)
秦皇岛市科技计划项目(项目编号:201805A096)。
关键词
老年
冠心病
经验性膳食炎症指数(eDⅡ)
炎症状态
old age
coronary heart disease
empirical dietary inflammation index(eDII)
inflammatory state
