摘要
肥胖症及减重后不能维持健康体质量的核心因素多为食物成瘾,食物成瘾在神经影像学中表现为奖赏网络与认知控制网络间神经环路的失衡。实时功能磁共振成像神经反馈(real time functional magnetic resonance imaging neurofeedback,rtfMRI-NF)作为一种新型生物反馈技术,已被应用于其他物质成瘾领域的临床研究和治疗中。在食物成瘾肥胖症中,rtfMRI-NF同样具有重塑异常脑功能、改善摄食行为并达到减重效果的潜力。本综述总结了肥胖患者食物成瘾的功能磁共振脑成像模型,探讨应用rtfMRI-NF作为其潜在治疗工具的可行神经靶点,并回顾了rtfMRI-NF在肥胖应用中的最新研究进展,为未来rtfMRI-NF在肥胖中的治疗策略和临床指导提供参考。
The central factor in obesity and the failure to maintain a healthy weight after weight loss is mostly food addiction,which is manifested in neuroimaging as an imbalance in the neural loop between the reward network and the cognitive control network.Real time functional magnetic resonance imaging neurofeedback(rtfMRI-NF),a novel biofeedback technique,has been applied in clinical research and treatment in other substance addiction fields.In food-addicted obesity rtfMRI-NF has the same potential to remodel abnormal brain functions,improve ingestive behaviors,and achieve weight loss.This review summarizes the functional magnetic resonance brain imaging models of food addiction in obese patients,explores the feasible neural targets for applying rtfMRI-NF as its potential therapeutic tool,and reviews the recent research progress of rtfMRI-NF in obesity applications,which will serve as a reference for the future therapeutic strategies and clinical guidance of rtfMRI-NF in obesity.
作者
李鑫
孙永兵
周菁
和俊雅
乔琦
林新贝
邹智
李中林
武肖玲
张弓
吕雪
李昊
胡扬喜
李凤丽
李永丽
LI Xin;SUN Yongbing;ZHOU Jing;HE Junya;QIAO Qi;LIN Xinbei;ZOU Zhi;LI Zhonglin;WU Xiaoling;ZHANG Gong;LÜXue;LI Hao;HU Yangxi;LI Fengli;LI Yongli(Department of Medical Imaging,Henan University People's Hospital/Henan Provincial People's Hospital,Zhengzhou 450003,China;Department of Medical Imaging,Zhengzhou University People's Hospital,Zhengzhou 450003,China;Department of Health Management,Henan Provincial People's Hospital,Henan Provincial Key Laboratory of Chronic Disease,Zhengzhou 450003,China;Department of Nuclear Medicine,Henan Provincial People's Hospital/Zhengzhou University People's Hospital,Zhengzhou 450003,China;Seven Oaks Health Management Center in Canada,China-Canada Health Engineering Research Institute,Hefei 230000,China;Department of Health Management,Henan Provincial People's Hospital,Zhengzhou 450003,China;Department of Health Management,Fuwai Central China Cardiovascular Hospital,Zhengzhou 450003,China;Department of Weight Loss Metabolism,Zhengzhou Center Hospital Affiliated with Zhengzhou University,Zhengzhou 450003,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2024年第5期175-180,共6页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金项目(编号:82071884)
国家重点研发计划项目(编号:2022YFC2010001)
河南省医学科技攻关计划项目(编号:SBGJ202302011)
河南省中青年卫生健康科技创新人才项目(编号:YXKC2020004)。
关键词
肥胖
食物成瘾
实时功能磁共振成像神经反馈
磁共振成像
奖赏功能
obesity
food addiction
real time functional magnetic resonance imaging neurofeedback
magnetic resonance imaging
reward function
