摘要
目的:探讨宫颈癌患者血清鳞状细胞癌抗原(SCC-Ag)、中性粒细胞与淋巴细胞比值(NLR)与临床病理特征及预后关系。方法:纳入2018年1月-2023年1月本院收治的108例宫颈癌患者为宫颈癌组,宫颈上皮内瘤病变(CIN)患者108例为CIN组,健康体检健康女性108例为对照组。比较3组血清SCC-Ag、NLR水平,分析宫颈癌组血清SCC-Ag、NLR水平与临床病理特征及与预后关系。结果:血清SCC-Ag、NLR水平,宫颈癌组(7.35±1.76、4.65±1.06)、CIN组(2.06±0.53、3.41±0.89)、对照组(0.54±0.12、1.53±0.34)依次降低(P<0.05)。宫颈癌患者血清SCC-Ag、NLR水平与病理类型、FIGO分期、病理分级、肌层浸润深度和盆腔淋巴结转移有关(P<0.05)。Kaplan-Meier显示,SCC-Ag、NLR高表达组总生存率、无病生存率均低于SCC-Ag、NLR低表达组,SCC-Ag高表达+NLR高表达组总生存率、无病生存率最低(均P<0.05)。结论:宫颈癌患者血清SCC-Ag、NLR水平与病理类型、FIGO分期、病理分级和肌层浸润深度等有关,且SCC-Ag、NLR水平越高患者预后越差。
Objective:To explore the correlation between the squamous-cell carcinoma antigen(SCC-Ag)level and neutrophil to lymphocyte ratio(NLR)of women with cervical cancer and their clinicopathological characteristics and prognosis.Methods:108women with cervical cancer in group A,108women with cervical intraepithelial neoplasia(CIN)in group B and 108healthy women in group C were enrolled in this study.The levels of SCC-Ag and NLR of the women were compared among the three groups.The correlation between the levels of SCC-Ag and NLR of women in group A and their clinicopathological characteristics and prognosis was analyzed.Results:The levels of serum SCC-Ag and NLR of the women in group A(7.35±1.76and 4.65±1.06),in group B(2.06±0.53and 3.41±0.89),and in group C(0.54±0.12and 1.53±0.34)had decreased gradually(P<0.05).The levels of the serum SCC-Ag and NLR of the women with cervical cancer were related to their pathological type,FIGO stage,pathological grade,depth of myometrial invasion and pelvic lymph node metastasis(P<0.05).Kaplan-Meier showed that the overall survival rate and the diseasefree survival rate of the women with the high expressions of SCC-Ag and NLR were significantly lower than those of the women with the low expressions of SCC-Ag and NLR.The overall survival rate and the disease-free survival rate of the women with high expressions of SCC-Ag and NLR were the lowest(all P<0.05).Conclusion:The levels of serum SCC-Ag and NLR of the women with cervical cancer are related to their pathological type,FIGO staging,pathological grading and depth of muscular invasion.The higher of the levels of serum SCC-Ag and NLR,the worse of the prognosis of the women.
作者
陈秀英
陈娜
高娜
崔建涛
李晓丹
张士表
CHEN Xiuying;CHEN Na;GAO Na;CUI Jiantao;LI Xiaodan;ZHANG Shibiao(Cangzhou Hospital of Traditional Chinese and Western Medicine,Cangzhou,Hebei Province,061000)
出处
《中国计划生育学杂志》
2024年第5期1067-1071,共5页
Chinese Journal of Family Planning
基金
河北省卫生健康项目计划(20232140)。
关键词
宫颈癌
鳞状细胞癌抗原
中性粒细胞与淋巴细胞比值
病理特征
预后
Cervical cancer
Squamous cell carcinoma antigen
Neutrophil lymphocyte ratio
Pathological characteristic
Prognosis
