摘要
目的:探究高强度聚焦超声(HIFU)消融治疗对子宫腺肌症效果及对患者子宫动脉血流参数、性激素的影响。方法:回顾性分析2022年6月-2023年6月本院收治的子宫腺肌症患者118例,按照治疗方式不同分为观察组(HIFU消融治疗,n=60)和对照组(病灶切除术,n=58),比较两组术前及术后月经血量[月经失血图(PBAC)]痛经程度[视觉模拟评分(VAS)]、子宫动脉血流参数[灌注指数(PI)、阻力指数(RI)、子宫动脉血流量(BFV)]、性激素[卵泡刺激素(FSH)、黄体生成激素(LH)、雌二醇(E_(2))]、不良反应及复发情况。结果:两组术后3、6个月时PBAC、痛经程度VAS评分以及不良反应(5.0%、3.5%)均无差异(P>0.05);观察组术后1d手术疼痛VAS评分(3.48±1.12分)低于对照组(4.20±1.32分)(P<0.05)。术后6个月时,两组PI、BFV、FSH、LH、E_(2)水平均低于术前,RI水平高于术前,但两组无差异;观察组和对照组各复发1例也无差异(均P>0.05)。结论:HIFU消融能够有效治疗子宫腺肌症,与手术治疗效果相当,但能够减轻患者术后疼痛程度。
Objective:To explore the effect of high intensity focused ultrasound(HIFU)ablation for treating patients with adenomyosis,and to study its influence on the uterine artery blood flow parameters values,sex hormones levels and pain of the patients.Methods:A retrospective analysis was performed on 118patients with adenomyosis admitted to hospital from June 2022to June 2023.According to the different treatment methods,these patients were divided into the observation group(60patients with treatment of HIFU ablation)and the control group(58patients with treatment of lesion resection).The preoperative and postoperative menstrual blood volume evaluated by pictorial blood loss assessment chart(PBAC),the dysmenorrhea degree evaluated by visual analogue score(VAS),the uterine artery blood flow parameters,such as perfusion index(PI),resistance index(RI)and uterine arterial blood flow volume(BFV),the level of sex hormones,such as follicle stimulating hormone(FSH),luteinizing hormone(LH),and estradiol(E_(2)),and the situations of the adverse reactions,fertility intention and the adenomyosis recurrence of the patients were compared between the two groups.Results:There were no statistically significant differences in the postoperative menstrual blood volume evaluated by PBAC in 3and 6months after surgery,the VAS score of dysmenorrhea degree and the adverse reactions rate(5.0%vs.3.5%)of the patients between the two groups(P>0.05).The VAS score of surgical pain(3.48±1.12points)of the patients in the observation group in 1dafter surgery was significantly lower than that(4.20±1.32points)of the patients in the control group(P<0.05).In the 6th month after surgery,the PI and BFV values,and the levels of FSH,LH and E_(2)of the patients in the two groups were significantly lower than those before operation,and the RI value of the patients in the two groups was significantly higher than that before operation,but all of which of the patients had no significant differences between the two groups.There was 1patient with adenomyosis recurrence in both groups,and the adenomyosis recurrence rate of the patients had no significant difference between the two groups(all P>0.05).Conclusion:HIFU ablation for treating the patients with adenomyosis has effectiveness,which has the same effect as the surgical treatment,but it can reduce the of postoperative pain degree of the patients.
作者
符芳慧
许远芳
林洁
FU Fanghui;XU Yuanfang;LIN Jie(Wanning People's Hospital,Wanning,Hainan Province,571500)
出处
《中国计划生育学杂志》
2024年第5期1113-1116,1120,共5页
Chinese Journal of Family Planning
关键词
子宫腺肌症
高强度聚焦超声消融
子宫动脉血流参数
性激素
术后疼痛
术后复发
Adenomyosis
High intensity focused ultrasound ablation
Uterine artery blood flow parameters
Sex hormone
Postoperative pain
Postoperative recurrence
