摘要
目的:探讨不同剂量丙硫氧嘧啶治疗妊娠合并甲状腺功能亢进症(简称甲亢)的临床效果。方法:选取2023年1—12月武威市中医医院收治的妊娠合并甲亢患者74例作为研究对象,按照信封抽签方式分为对照组和观察组,各37例。对照组开展低剂量丙硫氧嘧啶治疗,观察组开展高剂量丙硫氧嘧啶治疗。比较两组治疗效果。结果:治疗前,两组三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))、促甲状腺激素(TSH)、总甲状腺素(TT_(4))水平比较,差异无统计学意义(P>0.05);治疗后,两组FT_(3)、FT_(4)、TT_(4)水平低于治疗前,且观察组低于对照组,两组TSH水平高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.017)。治疗前,两组凝血酶原时间(PT)、血浆凝血酶时间(TT)、纤维蛋白原(FIB)、D-二聚体(D-D)水平比较,差异无统计学意义(P>0.05);治疗后,两组PT、TT短于治疗前,且观察组短于对照组,FIB、D-D水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。观察组不良妊娠结局总发生率低于对照组,差异有统计学意义(P=0.033)。结论:高剂量丙硫氧嘧啶治疗妊娠合并甲亢的效果较好,可以有效改善患者甲状腺功能、凝血功能,降低不良妊娠结局发生率,保证母婴健康,且安全性较高。
Objective:To explore the clinical effect of different doses of propylthiouracil in treatment of pregnancy with hyperthyroidism.Methods:A total of 74 pregnant patients with hyperthyroidism admitted to Wuwei Traditional Chinese Medicine Hospital from January 2023 to December 2023 were selected as the study subjects.They were divided into control group and observation group according to the envelope drawing method,with 37 cases in each group.The control group received low-dose propylthiouracil treatment,while the observation group received high-dose propylthiouracil treatment.The treatment effects of two groups were compared.Results:Before treatment,there was no significant difference in the levels of triiodothyronine(FT_(3)),free thyroxine(FT_(4)),thyroid-stimulating hormone(TSH)and total thyroxine(TT_(4))between the two groups(P>0.05).After treatment,the levels of FT_(3),FT_(4) and TT_(4) in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group,while the levels of TSH in the two groups were higher than those before treatment,and the levels of TSH in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.017).Before treatment,there was no significant difference in the prothrombin time(PT),plasma thrombin time(TT),fibrinogen(FIB)and D-dimer(D-D)levels between the two groups(P>0.05).After treatment,PT and TT in the two groups were shorter than those before treatment,and these indexes in the observation group were shorter than those in the control group,while the FIB and D-D levels in the two groups were lower than those before treatment,and these indexes in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).The total incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.033).Conclusion:The effect of high-dose propylthiouracil in treatment of pregnancy with hyperthyroidism is better,which can effectively improve the thyroid gland and blood coagulation functions of patients,reduce the incidence of adverse pregnancy outcomes,and ensure the health of mothers and infants,with high safety.
作者
陈秀梅
王财年
Chen Xiumei;Wang Cainian(Wuwei Traditional Chinese Medicine Hospital,Wuwei 733000,Gansu Province,China)
出处
《中国社区医师》
2024年第10期47-49,共3页
Chinese Community Doctors
