摘要
目的:探讨扶正升白汤对小细胞肺癌化疗后白细胞减少症患者白细胞计数、卡诺夫斯凯计分(KPS)的影响。方法:选取2020年1月至2021年3月河北中医药大学附属沧州中西医结合医院收治的需进行化疗的小细胞肺癌患者(化疗后白细胞减少)120例为研究对象,通过随机数字表法分为观察组(60例,皮下注射重组人粒细胞集落刺激因子+扶正升白汤)和对照组(60例,皮下注射重组人粒细胞集落刺激因子)。比较两组患者的临床疗效、中医证候积分、白细胞计数、中性粒细胞绝对值和KPS评分。结果:观察组患者的总有效率为88.33%(53/60),高于对照组的70.00%(42/60),差异有统计学意义(P<0.05)。与治疗前相比,两组患者治疗后中医证候积分降低,白细胞计数、中性粒细胞绝对值升高,KPS评分升高;且观察组患者治疗后上述指标优于对照组,差异均有统计学意义(P<0.05)。结论:扶正升白汤能显著提高小细胞肺癌化疗后白细胞减少症患者的白细胞计数,改善临床症状,提高KPS评分。
OBJECTIVE:To probe into the effects of Fuzheng Shengbai decoction on leukocytes level and Karnofsky performance score(KPS)of patients with leukopenia after chemotherapy for small cell lung cancer.METHODS:Totally 120 patients after chemotherapy for small cell lung cancer(leukopenia after chemotherapy)admitted into Cangzhou Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Hebei University of Chinese Medicine from Jan.2020 to Mar.2021 were extracted to be divided into the observation group(60 cases,subcutaneous injection of recombinant human granulocyte colony-stimulating factor+Fuzheng Shengbai decoction)and control group(60 cases,subcutaneous injection of recombinant human granulocyte colony-stimulating factor)via the random number table method.The clinical efficacy,traditional Chinese medicine syndrome score,white blood cell count,NEUT,absolute value of neutrophils and KPS score were compared between two groups.RESULTS:The total effective rate of observation group was 88.33%(53/60),higher than 70.00%(42/60)of control group,the difference was statistically significant(P<0.05).Compared with before treatment,traditional Chinese medicine syndrome score decreased,white blood cell count,NEUT and KPS score increased in two groups after treatment;the above indicators in the observation group were better than those in the control group after treatment,the differences were statistically significant(P<0.05).CONCLUSIONS:Fuzheng Shengbai decoction can obviously increase the white blood cell count in patients with leukopenia after chemotherapy for small cell lung cancer,improve the clinical symptoms and KPS score.
作者
陈晶晶
王振强
王洪亮
张庆江
赵芳
赵阳
董雪珊
周雍明
CHEN Jingjing;WANG Zhenqiang;WANG Hongliang;ZHANG Qingjiang;ZHAO Fang;ZHAOYang;DONG Xueshan;ZHOU Yongming(Dept.of Internal Traditional Chinese Medicine,Cangzhou Hospital of Integrated Chinese and Western Medicine Affiliated to Hebei University of Chinese Medicine,Hebei Cangzhou 061000,China;Dept.of Oncology,Shijiazhuang Ping’an Hospital,Shijiazhuang 050025,China;Dept.of Oncology,Chaoyang Emergency Rescue Hospital of Integrated Chinese and Western Medicine,Beijing 100023,China;Dept.of Oncology,Guang’anmen Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing 100053,China)
出处
《中国医院用药评价与分析》
2024年第5期556-559,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
河北省中医药管理局科研计划项目(No.2017279)。
关键词
扶正升白汤
化疗
小细胞肺癌
白细胞减少症
功能状态
Fuzheng Shengbai decoction
Chemotherapy
Small cell lung cancer
Leukopenia
Functional status
