摘要
目的通过比较台州市新确诊及既往HIV感染者影响因素差异,为进一步完善HIV感染者贫血防治措施提供科学依据。方法纳入浙江省台州市开展的台州HIV与衰老队列研究中2756例HIV感染者,包括620名新确诊感染者及2136名既往感染者。运用logistic回归分析模型分析并比较新确诊及既往HIV感染者贫血患病及影响因素。结果在接受调查的2756例HIV感染者中,贫血患病率为18.7%(516/2756)。其中新确诊的HIV感染者有620人,贫血患病率为23.6%(146/620)。既往感染者有2136人,贫血患病率为17.3%(370/2136)。多因素logistic回归分析模型分析结果显示,无论是新确诊感染者还是既往感染者,性别及CD4+T淋巴细胞(CD4细胞)均为贫血患病影响因素(P<0.05)。除此之外,新确诊感染者中的影响因素还有过瘦(OR=2.88,95%CI:1.56~5.33,P=0.001)、超重或肥胖(OR=0.47,95%CI:0.28~0.81,P=0.006)、结核病史(OR=11.16,95%CI:1.55~80.27,P=0.017)、轻度肾功能不全(OR=1.87,95%CI:1.07~3.25,P=0.027);既往感染者中的影响因素:年龄45~59岁(OR=2.05,95%CI:1.30~3.24,P=0.002)、年龄≥60岁(OR=3.48,95%CI:2.08~5.83,P<0.001)、受教育水平为高中及以上(OR=0.62,95%CI:0.44~0.90,P=0.010)、患糖尿病(OR=1.60,95%CI:1.04~2.47,P=0.034)、患高胆固醇血症(OR=0.73,95%CI:0.55~0.96,P=0.023)。结论台州市HIV感染者贫血患病率相对于国内同期HIV感染者人群较低。除性别、CD4+T淋巴细胞细胞计数水平外,新确诊感染者与既往感染者贫血患病影响因素不同。因此,在贫血防治与筛查工作中应高度重视HIV感染者贫血的精准干预。
Objective This study aims to explore and draw comparison in influencing factors between newly diagnosed and formerly reported HIV-infected persons in Taizhou City.The findings provide scientific evidence for improving preventative measures and treatment for anemia in HIV-infected individuals.Methods A total of 2756 HIV-infected individuals from the Comparative HIV and aging research in Taizhou(CHART)were recruited in Taizhou,Zhejiang Province,include 620 newly diagnosed cases and 2136 formerly reported cases.Logistic regression models were used to analyze the factors influencing anemia among HIV-infected individuals and draw comparion in influencing factors between newly diagnosed and formerly reported HIV-infected persons.Results Among the 2756 HIV-infected individuals surveyed,the prevalence of anemia was 18.7%(516/2,756).Among the 620 newly diagnosed HIV cases,the prevalence of anemia was 23.6%(146/620),while among the 2136 formerly reported HIV cases,the prevalence of anemia was 17.3%(370/2136).Multivariable logistic regression analysis showed that both newly diagnosed and previously infected individuals shared gender and CD4 count as influencing factors for anemia,in addition to which,among newly diagnosed cases,other influencing factors included underweight(OR=2.88,95%CI:1.56-5.33,P=0.001),overweight or obesity(OR=0.47,95%CI:0.28-0.81,P=0.006),history of tuberculosis(OR=11.16,95%CI:1.55-80.27,P=0.017),and mild renal insufficiency(OR=1.87,95%CI:1.07-3.25,P=0.027).Among Previously infected individuals,the influencing factors included the age group of 45-59 years(OR=2.05,95%CI:1.30~3.24,P=0.002),age≥60 years(OR=3.48,95%CI:2.08~5.83,P<0.001),education level of high school or above(OR=0.62,95%CI:0.44-0.90,P=0.010),diabetes(OR=1.60,95%CI:1.04-2.47,P=0.034),and hypercholesterolemia(OR=0.73,95%CI:0.55-0.96,P=0.023).Conclusions The prevalence of anemia among HIV-infected individuals in Taizhou City is relatively lower compared to other HIV-infected populations in China during the same period.Aside from gender and CD4 cell count,newly diagnosed and formerly reported HIV cases differ in the factors influencing anemia.Therefore,precise interventions of anemia among HIV-infected individuals should be emphasized in the prevention,screening,and treatment of anemia.
作者
李畅
汪剡灵
王婷婷
谢亚莉
林海江
陈潇潇
何纳
LI Chang;WANG Shanling;WANG Tingting;XIE Yali;LIN Haijiang;CHEN Xiaoxiao;HE Na(Department of Epidemiology,School of Public Health,Fudan University,Shanghai 200032,China;Yiwu Research Institute,Fudan University,Yiwu 322000,China;Taizhou Prefectural Center for Disease Control and Prevention,Taizhou 318000,China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2024年第4期409-416,共8页
Chinese Journal of Disease Control & Prevention
基金
国家自然科学基金(82173579)。
