摘要
急性肾损伤(acute kidney injury,AKI)发病率逐年升高,可导致患者住院时间延长甚至增加其病死率。糖尿病是AKI的独立危险因素,糖尿病患者往往使用降糖药物来控制血糖。研究表明,不同种类的降糖药对AKI的发生可能有一定的影响,包括二甲双胍、钠-葡萄糖协同转运蛋白2抑制剂、肠促胰岛素类似物(胰高血糖素样肽-1受体激动剂、二肽基肽酶4抑制剂)等。本文就以上问题针对相关药物与AKI发生的关系进行讨论。
A rising incidence of acute kidney injury(AKI)may lead to longer hospitalization stays and even greater mortality.Diabetes is an independent risk factor for AKI and using hypoglycemic agents has been a fundamental glycemic control in diabetics.Studies have shown that different types of hypo-glycemic agents may have an effect on the occurrence of AKI,including metformin,SGLT2 inhibitors and entero-insulin analogues(GLP-1 receptor agonists,DPP4 inhibitors).This review focused upon the rela-tionship between related drugs and AKI.
作者
郭丹宁
马梦青
曹长春
Guo Dan-ning;Ma Meng-qing;Cao Chang-chun(Department of Nephrology,Sir Run Run Hospital,Nanjing Medical University,Nanjing 211166,China)
出处
《临床肾脏病杂志》
2024年第5期422-426,共5页
Journal Of Clinical Nephrology
基金
江苏省卫生健康委医学科研重点项目(ZDB2020023)
江苏省研究生科研与实践创新计划(SJCX22_0658)。
关键词
急性肾损伤
降糖药
2型糖尿病
Acute kidney injury
Hypoglycaemic agents
Type 2 diabetes
