摘要
目的分析血清雌二醇(E2)、25-羟基维生素D3[25(OH)D3]及尿碘水平对分化型甲状腺癌(DTC)的预测价值。方法选取2021年9月至2022年9月雅安市人民医院收治的并经病理组织学确诊的190例DTC患者作为恶性组,并选取本院同期收治的125例甲状腺良性病变患者作为良性组,另选取甲状腺形态正常的健康体检者100名作为健康对照组,比较三组血清E2、25(OH)D3及尿碘水平,并比较不同临床特征的DTC患者血清E2、25(OH)D3及尿碘水平,采用ROC曲线分析血清E2、25(OH)D3及尿碘水平对DTC的预测价值。结果血清E2、尿碘水平:恶性组>良性组>健康对照组,25(OH)D3水平:恶性组<良性组<健康对照组,差异均有统计学意义(P<0.05)。血清E2、尿碘水平:肿瘤低分化程度患者>肿瘤中分化程度患者>肿瘤高分化程度患者;尿碘水平:T3-T4浸润深度患者>T1-T2浸润深度患者,淋巴结转移患者>无淋巴结转移患者;血清25(OH)D3水平:肿瘤低分化程度患者<肿瘤中分化程度患者<肿瘤高分化程度患者,T3-T4浸润深度患者<T1-T2浸润深度患者,淋巴结转移患者<无淋巴结转移患者,差异均有统计学意义(P<0.05)。ROC曲线分析显示,血清E2、25(OH)D3及尿碘水平联合预测DTC的敏感度、特异度、AUC为94.74%、92.80%、0.978,高于三指标单独检测(P<0.05)。结论血清E2、25(OH)D3及尿碘水平与DTC发生及病情进展有关,且三者联合对DTC的预测价值更高。
Objective To analyze the predictive value of serum estradiol(E2),25⁃hydroxyvita⁃min D3[25(OH)D3]and urine iodine levels in differentiated thyroid carcinoma(DTC).Methods 190 pa⁃tients with DTC who were admitted to Yaan People's Hospital from September 2021 to September 2022 and confirmed by histopathology were selected as the malignant group.Additionally,125 patients with benign thy⁃roid lesions were chosen as the benign group and 100 healthy individuals with normal thyroid morphology were selected as the healthy control group.Serum levels of E2,25(OH)D3 and urine iodine in the three groups were compared.Serum E2,25(OH)D3 and urine iodine levels in DTC patients with different clinical charac⁃teristics were compared.The predictive value of serum E2,25(OH)D3 and urine iodine levels in DTC was an⁃alyzed using ROC curves.Results Serum E2 and urine iodine levels decreased sequentially from the malig⁃nant group,to the benign group and finally to the healthy control group.The differences were statistically sig⁃nificant(P<0.05).Conversely,the 25(OH)D3 level increased sequentially across these groups.In patients with poorly differentiated carcinomas,moderately differentiated carcinomas,and highly differentiated carcino⁃mas,serum E2 and urine iodine levels decreased sequentially.Additionally,patients with T3⁃T4 infiltration depth had higher urine iodine levels compared to those with T1⁃T2 infiltration depth.Patients with lymph node metastasis also had higher urine iodine levels that those without.On the other hand,serum 25(OH)D3 levels increased sequentially in patients with poorly differentiated carcinomas,moderately differentiated carcinomas,and highly differentiated carcinomas.Serum 25(OH)D3 levels in patients with T3⁃T4 infiltration depth were lower than those in patients with T1⁃T2 infiltration depth.Serum 25(OH)D3 levels in patients with lymph node metastasis were lower than those in patients without.The differences were statistically significant(P<0.05).ROC curve analysis showed that the combination of serum E2,25(OH)D3 and urinary iodine had a sensitivity,specificity,and AUC of 94.74%,92.80%and 0.978,respectively,for predicting DTC.These val⁃ues were higher than those obtained using a single indicator(P<0.05).Conclusion Serum E2,25(OH)D3 and urine iodine levels are related to the occurrence and progression of DTC.The combination of all three fac⁃tors is more conducive to predicting DTC.
作者
杨福洲
宋锦丽
颜中
李明燕
YANG Fuzhou;SONG Jinli;YAN Zhong;LI Mingyan(Department of Nuclear Medicine,Ya'an People's Hospital,Ya'an,Sichuan,China,625000)
出处
《分子诊断与治疗杂志》
2024年第5期872-876,共5页
Journal of Molecular Diagnostics and Therapy
基金
雅安市科技计划项目(2018yyjskf17)。
