摘要
严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的COVID-19在全球范围内大流行,危害了人类健康和公共安全,随着对SARS-CoV-2的结构、功能和致病过程的了解,越来越多的潜在药物被开发。蛹虫草(Cordyceps militaris)是我国传统的药用真菌,具有显著的抗病毒作用,虫草素作为蛹虫草的主要活性成分能够与SARS-CoV-2刺突蛋白、主蛋白酶(Mpro)相结合,抑制病毒RNA依赖的RNA聚合酶(RDRP)活性,阻断SARS-CoV-2在机体内复制。蛹虫草还具有提升机体免疫力、修复受损组织的作用。本文概述虫草素抗SARS-CoV-2的机制和蛹虫草其他相关药理作用,以期为蛹虫草用于新型冠状病毒感染的辅助治疗提供参考。
COVID-19 caused by SARS-CoV-2 is a global pandemic disease,endangering human health and public safety.With the understanding of the structure,function and pathogenic process of SARS-CoV-2,more and more po-tential drugs are being developed.Cordyceps militaris is a traditional medicinal fungus that has significant antiviral effects.Cordycepin is the main active component of C.militaris which can combine with SARS-CoV-2 spike protein and main protease(Mpro),inhibit viral RdRp polymerase,and prevent SARS-CoV-2 from replicating in the body.C.militaris also has the function of improving the body′s immunity and repairing damaged tissues.The anti-SARS-CoV-2 mechanism of cordycepin and other related pharmacological functions of C.militaris were summarized.This re-view will provide reference for the adjuvant therapy of cordycepin for COVID-19.
作者
怀美玉
徐方旭
刘梦潜
董彩虹
HUAI Mei-yu;XU Fang-xu;LIU Meng-qian;DONG Cai-hong(College of Life Science,Shenyang 110034;Liaoning Key Lab.of Cordyceps militaris with Functional Val.,Shenyang 110034;Exp.Teach.Ctr.,Shenyang Normal Uni.,Shenyang 110034;Shenyang Functional Cordyceps militaris Indust.Technol.Res.Inst.,Shenyang 110034;Inst.of Microbiol.,Chinese Acad.of Sci.,Beijing 100101)
出处
《微生物学杂志》
CAS
CSCD
北大核心
2024年第2期109-119,共11页
Journal of Microbiology
基金
辽宁省科技厅面上项目(2023-MS-251)
辽宁省教育厅重点攻关项目(LJKZZ20220116)。
