摘要
目的研究阿利沙坦酯联合二甲双胍治疗老年高血压合并糖尿病患者的疗效。方法选择2021年8月~2023年5月收治的82例老年高血压合并糖尿病患者,采取随机数字表法分为对照组和观察组,各41例。对照组采用二甲双胍治疗,观察组采用阿利沙坦酯联合二甲双胍治疗。检测两组的疗效、血脂指标[总胆固醇(TC)、低密度胆固醇(LDL-C)和甘油三酯(TG)]、心功能[每搏输出量(SV)、左心室舒张末期血容量(EDV)、心输出量(CO)、射血分数(EF)和左心室收缩末期血容量(ESV)]、血清指标[miR-455、miR-126及miR-26a-5p]。结果观察组的有效率明显高于对照组(P<0.05);治疗后,两组的TC、LDL-C和TG水平明显降低(P<0.05),且观察组的TC、LDL-C和TG水平明显低于对照组(P<0.05);治疗后,两组的SV、ESV、EF、CO和EDV均明显改善(P<0.05),且观察组的SV、ESV、EF、CO和EDV明显优于对照组(P<0.05);治疗后,两组的血清miR-455、miR-126及miR-26a-5p水平均明显升高(P<0.05),且观察组的血清miR-455、miR-126及miR-26a-5p水平明显高于对照组(P<0.05)。结论阿利沙坦酯联合二甲双胍对老年高血压合并糖尿病患者有显著的疗效。
Objective To study the effect of allisartan isoproxil combined with metformin on elderly patients with hypertensive patients with diabetes.Methods Selected 82 cases of elderly patients with hypertensive patients with diabetes from August 2021 to May 2023,divided into the control group and the observation group randomly,41 cases in each group.The control group was treated with metformin,while the observation group was treated with allisartan isoproxil combined with metformin.The clinical efficacy,blood lipid indexes[total cholesterol(TC),low-density cholesterol(LDL-C)and triglycerides(TG)],cardiac function[stroke output(SV),left ventricular end-diastolic blood volume(EDV),cardiac output(CO),ejection fraction(EF)and left ventricular end-systolic blood volume(ESV)],serum indicators(miR-455,miR-126 and miR-26a-5p)of the two groups were measured.Results The total effective rate of the observation group was significantly higher(P<0.05).After treatment,the levels of TC,LDL-C,and TG in both groups were significantly reduced(P<0.05),and the levels of TC,LDL-C,and TG in the observation group were significantly lower(P<0.05).After treatment,the SV,ESV,EF,CO and EDV of both groups were significantly improved(P<0.05),and the SV,ESV,EF,CO and EDV of the observation group were significantly better(P<0.05).After treatment,the serum levels of miR-455,miR-126,and miR-26a-5p in both groups were significantly increased(P<0.05),and the serum levels of miR-455,miR-126,and miR-26a-5p in the observation group were significantly higher(P<0.05).Conclusion Allisartan isoproxil combined with metformin has a significant effect on elderly patients with hypertension and diabetes.
作者
张玲燕
ZHANG Ling-yan(Department of Pharmacy,Nantong Geriatric Rehabilitation Hospital,Nantong 226001,China)
出处
《中国处方药》
2024年第5期122-124,共3页
Journal of China Prescription Drug
关键词
阿利沙坦酯
二甲双胍
高血压合并糖尿病
脂代谢
心功能
血清指标
Allisartan isoproxil
Metformin
Hypertension with diabetes
Lipid metabolism
Cardiac function
Serum indicators
