摘要
甲状腺相关性眼病(TAO)是一种自身免疫性疾病,其病因和发病机制尚未完全明确,目前普遍认为其发生是免疫、遗传、环境等因素共同作用的结果。近年来,学者们开始关注微生物对TAO的影响,认为眼表及肠道菌群失调后能激发免疫系统发生一系列的免疫应答,诱发TAO的自身免疫反应。“肠-眼轴”可能是TAO发病的重要因素之一,肠道菌群及其代谢物可能通过血液循环和淋巴系统影响眼表组织,这种“肠-眼轴”的相互作用可能通过多种途径影响TAO的发生和发展,包括免疫细胞的迁移、交叉免疫反应和代谢物的循环。本文就眼表菌群及肠道菌群失调与TAO的研究进展进行综述,探讨其菌群参与TAO发生发展的可能机制,为TAO的诊断与治疗提供新的思路。
Thyroid-associated ophthalmopathy(TAO)is an autoimmune disease whose etiology and pathogenesis have not yet been clarified.It is generally believed that its occurrence is the result of a combination of immune,genetic,environmental,and other factors.In recent years,scholars have paid more attention to the influence of microorganisms on TAO,and they found that alterations of the ocular surface and intestinal flora can stimulate the immune system to generate a series of immune responses,which induces autoimmune responses to TAO.The“gut-eye axis”may be an important factor involved in the development of TAO.The intestinal flora and its metabolites may affect ocular tissues through blood circulation and the lymphatic system.This interaction between the gut and eye axis may affect the occurrence and development of TAO through various pathways,including migration of immune cells,cross immune reactions,and metabolite circulation.This article reviews the research progress on the correlation between alterations of the ocular surface and intestinal flora and TAO and explores the possible mechanisms of the flora involvement in the development of TAO,providing new ideas for the diagnosis and treatment of TAO.
作者
张皙苒
张馨心
康志明
董魁
孙斌
ZHANG Xiran;ZHANG Xinxin;KANG Zhiming;DONG Kui;SUN Bin(First Clinical College of Shanxi Medical University,Taiyuan 030001,Shanxi Province,China;Central Microbiology Laboratory,Shanxi Eye Hospital,Taiyuan 030002,Shanxi Province,China;Department of Orbital Ophthalmology,Shanxi Eye Hospital,Taiyuan 030002,Shanxi Province,China)
出处
《眼科新进展》
CAS
北大核心
2024年第6期494-498,共5页
Recent Advances in Ophthalmology
基金
山西省自然科学研究面上项目(编号:20210302123343)
山西省眼科医院院内创新基金(编号:C202201)。
关键词
甲状腺相关性眼病
肠道菌群
眼表菌群
肠-眼轴
thyroid-associated ophthalmopathy
intestinal flora
ocular surface flora
gut-eye axis
