摘要
目的:观察雷火灸联合耳针防治结直肠癌化疗毒副反应及对患者癌痛、睡眠质量改善效应。方法:将河南理工大学第一附属医院符合纳入标准2020年1月—2022年6月住院的116例结直肠癌患者,按随机数字表法分为参照组(58例)、联合组(58例)。参照组给予化疗药物治疗,联合组在化疗基础上使用雷火灸联合耳针治疗。比较2组临床疗效、化疗毒副反应、血细胞水平白细胞(White blood cells,WBC)、血红蛋白(Hemoglobin,Hb)、血小板(Platelet,PLT)、淋巴细胞计数(Lymphocyte count,TLC)、治疗前后癌痛程度以视觉模拟评分法(Visual analog scales,VAS)评估、癌因性疲乏(Cancer-related fatigue,CRF)以Piper疲乏修正量表(Piper fatigue fcale-revised,PFS-R)评估、睡眠质量以匹兹堡睡眠质量指数量表(Pittsburgh Sleep Quality Index,PSQI)评估。结果:联合组ORR、DCR为82.76%、100.00%,与参照组的68.97%、91.38%比较,差异无统计学意义(P>0.05);治疗后联合组胃肠道反应、贫血、骨髓抑制、神经毒性发生率均低于参照组(P<0.05);治疗后联合组TLC、PLT、WBC、Hb水平高于参照组(P<0.05);治疗后联合组VAS、PFS-R、PSQI评分较治疗前降低,且低于参照组(P<0.05)。结论:雷火灸联合耳针治疗能减少结直肠癌患者化疗后毒副反应出现,缩小病灶,减轻患者癌痛,提高睡眠质量,改善身体疲乏,利于病情恢复。
Objective:To observe the effects of thunder-fire moxibustion combined with auricular acupuncture on the prevention and treatment of chemotherapy toxic and side effects of colorectal cancer and the improvement of cancer pain and sleep quality in patients.Methods:116 colorectal cancer patients who were hospitalized in our hospital between January 2020 and June 2022 who met the inclusion criteria were divided into a reference group(58 cases)and a combination group(58 cases)according to the random number table method.The reference group was treated with chemotherapy drugs,and the combination group was treated with thunder-fire moxibustion combined with auricular acupuncture on the basis of chemotherapy.Compare the clinical efficacy,chemotherapy toxic and side effects,blood cell levels[white blood cells(WBC),hemoglobin(Hb),platelet(PLT),lymphocyte count(TLC)],before and after treatment between the two groups Cancer pain level assessed by visual analog scales(VAS),cancer-related fatigue(CRF)assessed by Piper fatigue fcale-revised(PFS-R),sleep quality assessed by the Pittsburgh Sleep Quality Index(PSQI).Results:The ORR and DCR of the combination group were 82.76% and 100.00%,compared with 68.97% and 91.38% of the reference group,the difference was not statistically significant(P>0.05);gastrointestinal reactions,anemia,and bone marrow suppression in the combination group after treatment,the incidence of neurotoxicity were lower than those of the reference group(P<0.05);the TLC,PLT,WBC,and Hb levels of the combination group after treatment were higher than those of the reference group(P<0.05);the VAS,PFS-R,and PSQI scores of the combination group after treatment It was lower than before treatment and lower than that of the reference group(P<0.05).Conclusion:Thunderfire moxibustion combined with auricular acupuncture can reduce the occurrence of toxic and side effects in patients with colorectal cancer after chemotherapy,shrink the lesions,relieve patients’cancer pain,improve sleep quality,improve physical fatigue,and facilitate recovery.
作者
李娜娜
宫嘉
张晓晓
LI Nana;GONG Jia;ZHANG Xiaoxiao(The Second People's Hospital of Jiaozuo City,Henan Province,The First Affiliated Hospital of Henan Polytechnic University,He’nan Jiaozuo 454000,China)
出处
《中医药临床杂志》
2024年第5期956-960,共5页
Clinical Journal of Traditional Chinese Medicine
关键词
结直肠癌
雷火灸
耳针
毒副反应
癌痛
Colorectal cancer
Thunder-fire moxibustion
Ear acupuncture
Toxic and side effects
Cancer pain
