摘要
干眼症是一种常见的多因素眼表疾病,与眼表炎症、泪膜不稳定等有关.近年来,大量研究表明围手术期用药、手术创伤、患者自身因素、术后炎性反应等与围手术期干眼症相关.环孢素可选择性地调节T细胞,保护杯状细胞与结膜上皮细胞并促进泪液分泌,从而有效缓解患者干眼症状,提高手术精确度与患者满意度.目前环孢素已被广泛应用于围手术期干眼症的临床治疗中,并取得良好效果.
Dry eye disease(DED)is a multifactorial and prevalent disease associated with ocular surface inflammation and impaired lubrication.In recent years,numerous studies have demonstrated that perioperative pharmacological use,surgical trauma,individual factors,and postoperative inflammatory responses are associated with postoperative DED.Cyclosporine selectively regulates T cells,protecting goblet cells and conjunctival epithelial cells while promoting tear secretion.As a result,it effectively alleviates dry eye symptoms in patients,improving the precision of surgeries and patient satisfaction.Currently,cyclosporine is widely used in the clinical treatment of perioperative dry eye,achieving favorable outcomes.
作者
韩艺琳
张凤妍
Han Yilin;Zhang Fengyan(Department of Ophthalmology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《国际眼科纵览》
2024年第2期103-108,共6页
International Review of Ophthalmology
基金
国家自然科学基金(81970785)。
关键词
环孢素
干眼症
围手术期
cyclosporine
dry eye disease
perioperative period
