摘要
目的分析德谷门冬双胰岛素(Insulin Degludec/Insulin Aspart,IDegAsp)治疗口服降糖药(Oral Antidiabetic Drugs,OADS)控制不佳2型糖尿病的效果。方法选取2022年8月—2023年7月济南市章丘区中医医院收治的92例OADS控制不佳2型糖尿病患者为研究对象,参照随机数表法分为两组,各46例。对照组采用甘精胰岛素治疗,研究组采用IDegAsp治疗。比较两组血糖水平、血糖波动值、低血糖发生率。结果治疗3个月后,研究组糖化血红蛋白、餐后2 h血糖、空腹血糖均低于对照组,差异有统计学意义(P均<0.05);研究组血糖标准差、24 h平均血糖值、餐后血糖波动值均低于对照组,差异有统计学意义(P均<0.05)。研究组血糖达标时间(6.15±1.52)d短于对照组的(7.89±1.60)d,差异有统计学意义(t=5.347,P<0.05)。两组低血糖发生率对比,差异无统计学意义(P>0.05)。结论IDegAsp能够有效改善OADS控制不佳2型糖尿病患者的血糖值,抑制其血糖波动,且未增加低血糖发生风险。
Objective To analyze the effect of insulin degludec/insulin aspart(IDegAsp)on type 2 diabetes mellitus poorly controlled by oral antidiabetic agents(OADS).Methods Ninety-two patients with type 2 diabetes with poorly controlled OADS treated in Zhangqiu District Hospital of Traditional Chinese Medicine of Jinan City from August 2022 to July 2023 were selected as the study objects,and they were divided into two groups with 46 cases each according to random number table method.The control group was treated with insulin glargine,and the study group was treated with IDegAsp.Blood glucose level,blood glucose fluctuation value and incidence of hypoglycemia were compared between the two groups.Results After 3 months of treatment,the glycosylated hemoglobin,2 h postprandial blood glucose and fasting blood glucose in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The blood glucose standard deviation,24 h average blood glucose value and postprandial blood glucose fluctuation value of the study group were lower than those of the control group,and the differences were statistically significant(all P<0.05).The blood glucose standard time of the study group(6.15±1.52)d was shorter than that of the control group(7.89±1.60)d,and the difference was statistically significant(t=5.347,P<0.05).There was no significant statistically difference in the incidence of hypoglycemia between the two groups(P>0.05).Conclusion IDegAsp can effectively improve the blood glucose value of type 2 diabetes patients with poorly controlled OADS,inhibit their blood glucose fluctuations,and does not increase the risk of hypoglycemia.
作者
李燕祥
刘永兰
石文霞
LI Yanxiang;LIU Yonglan;SHI Wenxia(Department of Outpatient Western Pharmacy,Zhangqiu District Hospital of Traditional Chinese Medicine,Jinan,Shandong Province,250200 China;Department of Intravenous Preparation Center,Zhangqiu District Hospital of Tra-ditional Chinese Medicine,Jinan,Shandong Province,250200 China)
出处
《系统医学》
2024年第8期134-136,144,共4页
Systems Medicine
关键词
德谷门冬双胰岛素
甘精胰岛素
口服降糖药
血糖控制不佳
2型糖尿病
Insulin degludec/insulin aspart
Insulin glargine
Oral antidiabetic agents
Poor blood glucose control
Type 2 diabetes
