摘要
目的基于国家中药复方专利探讨酒精性肝病的用药规律。方法检索中国专利公布公告网1985年9月至2023年7月治疗酒精性肝病的中药复方专利,运用古今医案云平台(V2.3.5)和IBM SPSS Modeler对专利复方进行用药频次统计,药物性味、归经和功效分析,配伍关联规则分析与聚类分析。结果共纳入专利55项,涉及药物270味;用药频次最高的药物是丹参,药性以寒、温为主,药味以苦、甘为主,多归肝、脾、胃、肺经,功效以清热解毒为主。支持度最高药对为柴胡-丹参,支持度最高角药为柴胡+丹参-泽泻;高频药物聚类分析获得3个药物组合。结论中药复方专利治疗酒精性肝病以清热解毒为基本治法,注重寒温并用、从肠治肝。
Objective To study the medication rule of alcoholic liver disease based on the national patent of Chinese medicine compound prescription.Methods The patents of Chinese medicine compound prescription for the treatment of alcoholic liver disease from September 1985 to July 2023 were searched on the China Patent Publication and Announcement Website.The frequency of drug,the analysis of nature and flavour,channel tropism,and efficacy of drug,compatibility association rule analysis and cluster analysis were conducted using the Ancient and Modern Medical Records Cloud Platform(V2.3.5)and IBM SPSS Modeler.Results A total of 55 patents were included,involving 270 kinds of drugs.The most frequently used drug was Salviae Miltiorrhizae Radix Et Rhizoma.The drug natures were mainly cold and warm,the drug flavours were mainly bitter and sweet,mostly return to the liver,spleen,stomach,and lung channels,and the efficacy was mainly to clear heat and remove toxicity.The couplet medicines with the highest degree of support was Bupleuri Radix-Salviae Miltiorrhizae Radix Et Rhizoma,and the triple medicines with the highest degree of support was Bupleuri Radix plus Salviae Miltiorrhizae Radix Et Rhizoma-Alismatis Rhizoma.Three drug combinations were obtained by high-frequency drug cluster analysis.Conclusion The basic treatment of alcoholic liver disease is to clear heat and remove toxicity,pay attention to the combination of cold and warm,and treat liver from intestine.
作者
苏新
江锋
高悦
薛婧
SU Xin;JIANG Feng;GAO Yue;XUE Jing(The First School of Clinical Medicine,Beijing University of Chinese Medicine,Beijing 100700,China;Department of Gastroenterology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《中国医药导报》
CAS
2024年第11期6-9,共4页
China Medical Herald
基金
国家科技重大专项项目(2018ZX10725-509-002)
北京中医药大学东直门医院科技创新专项项目(DZMKJCX-2023-015)。
关键词
酒精性肝病
中药复方
国家专利
用药规律
Alcoholic liver disease
Chinese medicine compound prescription
National patent
Medication rule
