摘要
目的探讨低温等离子消融术联合腺样体切除术治疗阻塞性睡眠呼吸暂停综合征患儿的效果及对术后生活质量的影响。方法选取2021年1月至2022年1月我院收治的120例阻塞性睡眠呼吸暂停综合征患儿,以随机数字表法将其分为对照组和观察组,各60例。对照组行常规扁桃体剥离术治疗,观察组采用低温等离子消融术联合腺样体切除术治疗。比较两组的治疗效果。结果观察组的治疗总有效率为96.67%,高于对照组的86.67%(P<0.05)。治疗后,两组的夜间最低血氧饱和度[LSa(O_(2))]高于治疗前,氧减指数(ODI)、呼吸暂停低通气指数(AHI)低于治疗前,且观察组优于对照组(P<0.05)。治疗后,观察组的丙二醛(MDA)、3-硝基酪氨酸(3-NT)水平低于对照组,超氧化物歧化酶(SOD)、还原型谷胱甘肽(GSH)水平高于对照组(P<0.05)。治疗后15、30、60 d,两组的儿童阻塞性睡眠呼吸暂停低通气综合征特异性生活质量调查表(OSA-18)评分均低于治疗前(P<0.05);治疗后15、30 d,观察组的OSA-18评分低于对照组(P<0.05);治疗后60 d,两组的OSA-18评分无明显差异(P>0.05)。结论低温等离子消融术联合腺样体切除术治疗阻塞性睡眠呼吸暂停综合征患儿的效果明确,可以改善通气功能,减轻氧化应激反应,最终提升生活质量,值得应用及推广。
Objective To investigate the effect of low temperature plasma ablation combined with adenoidectomy on children with obstructive sleep apnea syndrome and its influence on postoperative quality of life.Methods A total of 120 children with obstructive sleep apnea syndrome admitted in our hospital from January 2021 to January 2022 were selected and divided into control group and observation group by random number table method,with 60 cases in each group.The control group was treated with conventional tonsillectomy,and the observation group was treated with low temperature plasma ablation combined with adenoidectomy.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was 96.67%,which was higher than 86.67%in the control group(P<0.05).After treatment,the nocturnal lowest oxygen saturation[LSa(O_(2))]in the two groups was higher than that before treatment,and the oxygen desaturation index(ODI)and apnea hypopnea index(AHI)were lower than those before treatment,and those in the observation group were better than the control group(P<0.05).After treatment,the levels of malondialdehyde(MDA)and 3-nitrotyrosine(3-NT)in the observation group were lower than those in the control group,and the levels of superoxide dismutase(SOD)and reduced glutathione(GSH)were higher than those in the control group(P<0.05).At 15,30 and 60 d after treatment,the score of Disease Specific Quality of Life for Children with Obstructive Sleep Apnea 18 Items Survey(OSA-18)in the two groups was lower than that before treatment(P<0.05);at 15 and 30 d after treatment,the OSA-18 score of the observation group was lower than that of the control group(P<0.05);at 60 d after treatment,there was no significant difference in OSA-18 score between the two groups(P>0.05).Conclusion Low temperature plasma ablation combined with adenoidectomy is effective in the treatment of children with obstructive sleep apnea syndrome,it can improve ventilation function,reduce oxidative stress response,and ultimately improve the quality of life,which is worthy of application and promotion.
作者
曾传道
周永玲
ZENG Chuandao;ZHOU Yongling(Otolaryngology Department,Ankang Central Hospital,Ankang 725000,China)
出处
《临床医学研究与实践》
2024年第17期70-74,共5页
Clinical Research and Practice
