摘要
目的比较对高胆红素血症新生儿开展不同蓝光照射方式治疗的疗效及安全性。方法108例高胆红素血症新生儿,按照随机数字表法分为间歇组和连续组,每组54例。间歇组接受间歇性蓝光照射治疗,连续组接受连续蓝光照射治疗。比较两组患儿血清总胆红素水平、总光照时间、黄疸消退时间与住院时间、不良事件发生率。结果治疗48、96 h时,间歇组患儿的血清总胆红素水平分别为(211.29±20.19)、(112.18±10.23)μmol/L,均低于连续组的(245.81±19.98)、(143.19±9.98)μmol/L(P<0.05)。两组患儿的黄疸消退时间、住院时间比较差异无显著性(P>0.05)。间歇组患儿总光照时间为(3.02±0.51)d,显著短于连续组的(4.20±0.65)d(P<0.05)。间歇组患儿不良事件发生率为5.56%(3/54),低于连续组的24.07%(13/54)(P<0.05)。结论对高胆红素血症新生儿实施间歇性蓝光照射治疗效果肯定,与连续蓝光照射治疗效果相当,但不良事件发生率显著更低,具有推广价值。
Objective To compare the efficacy and safety of different blue light irradiation methods in the treatment of neonatal hyperbilirubinemia.Methods 108 cases of neonatal hyperbilirubinemia were divided into intermittent group and continuous group according to random number table method,each with 54 cases.The intermittent group received intermittent blue light irradiation,and the continuous group received continuous blue light irradiation.Both groups were compared in terms of serum total bilirubin levels,total lighting time,jaundice subsidence time,length of hospital stay,and incidence of adverse reactions.Results After 48 and 96 h of treatment,the serum total bilirubin levels in the intermittent group were(211.29±20.19)and(112.18±10.23)μmol/L,which were lower than(245.81±19.98)and(143.19±9.98)μmol/L in the continuous group(P<0.05).There was no significant difference in the jaundice subsidence time and length of hospital stay between the two groups(P>0.05).The total lighting time in the intermittent group was(3.02±0.51)d,which was significantly shorter than the continuous group's(4.20±0.65)d(P<0.05).The incidence of adverse events in the intermittent group was 5.56%(3/54),which was lower than the continuous group's 24.07%(13/54)(P<0.05).Conclusion In the treatment of neonates with hyperbilirubinemia,intermittent blue light irradiation is definitely effective and comparable to continuous blue light irradiation,but it has a significantly lower incidence rate of adverse reactions,which has the value of popularization.
作者
陈燕红
林志成
CHEN Yan-hong;LIN Zhi-cheng(Department of Pediatrics,Jinjiang City Hospital(Shanghai Sixth Hospital Fujian Hospital),Quanzhou 362200,China)
出处
《中国现代药物应用》
2024年第10期55-57,共3页
Chinese Journal of Modern Drug Application
