摘要
目的分析解郁通络消瘿汤联合常规西医治疗桥本甲状腺炎的临床效果。方法2020年1月—2022年2月宜兴市中医医院收治的102例桥本甲状腺炎患者,分为对照组与研究组,各51例,方法为随机数字表法。对照组接受左甲状腺素钠片治疗,研究组在此基础上接受解郁通络消瘿汤治疗,两组均治疗3个月。分析两组治疗3个月后疗效,治疗前、治疗3个月后甲状腺功能、中医证候评分、血清微小核糖核酸(micro ribonucleic acid,miRNAs)表达水平。结果治疗3个月后,研究组总有效率为92.16%(47/51),高于对照组的80.39%(41/51)(P<0.05)。与治疗前比较,治疗3个月后两组血清甲状腺球蛋白抗体(thyroglobulin antibody,TGAb)、甲状腺过氧化物酶抗体(thyroid peroxidase antibody,TPOAb)、促甲状腺激素(thyroid stimulating hormone,TSH)水平,颈部梗塞、颈部肿大、食少纳呆、情绪抑郁的得分,血清微小核糖核酸-146a(micro ribonucleic acid-146a,miR-146a)、微小核糖核酸-454(micro ribonucleic acid-454,miR-454)、微小核糖核酸-155(micro ribonucleic acid-155,miR-155)表达水平降低,且研究组更低(P<0.05);两组血清游离甲状腺素(free thyroxine,FT4)、游离三碘甲腺原氨酸(free triiodothyronine,FT3)水平升高,且研究组更高(P<0.05)。结论解郁通络消瘿汤联合常规西医治疗桥本甲状腺炎的临床效果确切,可降低中医证候评分,改善甲状腺功能,调节miRNAs表达水平。
Objective To analyze the clinical effect of Jieyu Tongluo Xiaoying Decoction(解郁通络消瘿汤)combined with conventional western medicine in the treatment of Hashimoto′s thyroiditis.Methods A total of 102 patients with Hashimoto′s thyroiditis admitted to the hospital from January 2020 to February 2022 were divided into the control group and the study group,with 51 cases in each group.The method was random number table.The control group was treated with levothyroxine sodium tablets,and the study group was treated with Jieyu Tongluo Xiaoying Decoction on this basis.Both groups were treated for 3 months.The efficacy,thyroid function,scores of traditional Chinese medicine syndrome and serum expression levels of micro ribonucleic acid(miRNAs)were analyzed before and after 3 months of treatment.Results After 3 months of treatment,the total effective rate of the study group was 92.16%(47/51),which was higher than 80.39%(41/51)of the control group(P<0.05).Compared with those before treatment,the serum levels of thyroglobulin antibody(TGAb),thyroid peroxidase antibody(TPOAb),thyroid stimulating hormone(TSH),the scores of neck infarction,neck enlargement,hypoglycemia and depression,serum expression levels of micro ribonucleic acid-146a(miR-146a),micro ribonucleic acid-454(miR-454)and micro ribonucleic acid-155(miR-155)in the two groups after 3 months of treatment decreased,and the levels were lower in the study group(P<0.05).The serum levels of free thyroxine(FT4)and free triiodothyronine(FT3)increased in the two groups,and higher in the study group(P<0.05).Conclusion Jieyu Tongluo Xiaoying Decoction combined with conventional western medicine in the treatment of Hashimoto′s thyroiditis had a definite clinical effect,which could reduce the scores of traditional Chinese medicine syndrome,improve thyroid function and regulate the expression levels of miRNAs.
作者
陈婧
戴欣珏
车名花
姚丽琴
CHEN Jing;DAI Xinjue;CHE Minghua;YAO Liqin(Department of Endocrinology,Yixing Hospital of Traditional Chinese Medicine,Yixing 214200,Jiangsu,China)
出处
《辽宁中医杂志》
CAS
北大核心
2024年第6期82-85,共4页
Liaoning Journal of Traditional Chinese Medicine
关键词
桥本甲状腺炎
解郁通络消瘿汤
中医证候
甲状腺功能
微小核糖核酸
Hashimoto′s thyroiditis
Jieyu Tongluo Xiaoying Decoction(解郁通络消瘿汤)
traditional Chinese medicine syndrome
thyroid function
micro ribonucleic acid
