摘要
目的探讨桑杏苈黄汤在痰热闭肺证急性喘息性支气管炎(acute asthmatic bronchitis,AAB)患儿治疗中的应用。方法80例2019年9月—2023年5月泰州市姜堰中医院儿科门诊及住院部收治的痰热闭肺证AAB患儿以随机数字表法将其分为对照组(40例)和观察组(40例)。两组患儿均给予常规治疗,对照组在此基础上给予吸入用布地奈德混悬液、吸入用异丙托溴铵溶液、硫酸特布他林雾化吸入用溶液进行治疗,观察组在对照组基础上给予桑杏苈黄汤进行治疗,两组均持续治疗1周。对比对照组和观察组治疗1周后疗效,治疗前和治疗1周后中医证候评分、炎性因子及治疗期间安全性情况。结果与对照组比较,治疗1周后,观察组总有效率较高[95.00%(38/40)vs 77.50%(31/40),P<0.05]。与对照组比较,观察组喘息、咳嗽、肺部啰音消失及发热、气促缓解时间均较短(P<0.05)。与治疗前比较,两组治疗1周后的发热、喘息、咳嗽、痰鸣、紫绀、鼻煽评分及血清嗜酸性粒细胞(eosinophils,EOS)、免疫球蛋白E(immunoglobulin E,IgE)、白细胞介素-6(interleukin-6,IL-6)水平均降低,观察组低于对照组(P<0.05)。与对照组比较,治疗期间,观察组不良反应发生率较低[7.50%(3/40)vs 25.00%(10/40),P<0.05]。结论桑杏苈黄汤可明显改善痰热闭肺证AAB患儿中医证候,减轻患儿炎症反应,进而有利于促进患儿临床症状的改善,提高临床疗效,且具有较高安全性。
Objective To discuss the application of Sangxing Lihuang Decoction(桑杏苈黄汤)in the treatment of children with phlegm-heat closing lung syndrome of acute asthmatic bronchitis(AAB).Methods Eighty cases of children with phlegm-heat closing lung syndrome of AAB admitted to the department of pediatrics in Jiangyan Hospital of Traditional Chinese medicine were selected from September 2019 to May 2023 and were divided into the control group(40 cases)and the observation group(40 cases)by random number table method.The two groups were given routine treatment.The control group was given budesonide suspension for inhalation,ipratropium bromide solution for inhalation,terbutaline sulfate aerosol inhalation solution on this basis for treatment,and the observation group was given Sangxing Lihuang Decoction on the basis of the control group.Both groups were treated for 1 week.The efficacy after 1 week of treatment,times of clinical symptom relief,hospitalization,scores of traditional Chinese medicine symptoms,inflammatory factor before and after 1 week of treatment and security during treatment in the control group and the observation group were compared.Results Compared with that of the control group,the rate of total effective after 1 week of treatment in the observation group was higher[95.00%(38/40)vs 77.50%(31/40),P<0.05].Compared with those of the control group,the disappearance times of wheezing,cough and lung rale,the remission times of fever and shortness of breath in the observation group were shorter(P<0.05).Compared with those before treatment,after 1 week of treatment,the scores of fever,wheezing,cough,phlegm,cyanosis,nasal irritation,thick yellow expectorationand serum levels of eosinophil(EOS),immunoglobulin E(IgE)and interleukin-6(IL-6)in the two groups decreased,and the indexes of the observation group were lower than those of the control group(P<0.05).Compared with that of the control group,the rate of adverse reactions during treatment in the observation group was lower[7.50%(3/40)vs 25.00%(10/40),P<0.05].Conclusion Sangxing Lihuang Decoction could obviously improve the traditional Chinese medicine symptoms of children with phlegm-heat closing lung syndrome of AAB,reduce the inflammatory reaction and then help to improve the clinical symptoms and the clinical efficacy,and with high safety.
作者
陈研
周海霞
丁婷
CHEN Yan;ZHOU Haixia;DING Ting(Department of Pediatrics,Jiangyan Hospital of Traditional Chinese Medicine,Taizhou 225500,Jiangsu,China)
出处
《辽宁中医杂志》
CAS
北大核心
2024年第6期96-99,共4页
Liaoning Journal of Traditional Chinese Medicine
关键词
急性喘息性支气管炎
痰热闭肺证
桑杏苈黄汤
吸入用布地奈德混悬液
吸入用异丙托溴铵溶液
硫酸特布他林雾化吸入用溶液
中医证候
炎症反应
acute asthmatic bronchitis
phlegm-heat closing lung syndrome
Sangxing Lihuang Decoction(桑杏苈黄汤)
budesonide suspension for inhalation
ipratropium bromide solution for inhalation
terbutaline sulfate aerosol inhalation solution
traditional Chinese medicine symptom
inflammatory reaction
