摘要
目的 分析氨基末端脑钠肽前体(NT-proBNP)、D-二聚体(D-D)、C反应蛋白(CRP)检测对中老年急性脑梗死(ACI)患者的诊断价值。方法 选取中老年急性脑梗死患者52例为观察组[根据病灶直径不同分为大面积梗死组(>5 cm)10例、中面积梗死组(≤5 cm,>3 cm)16例、小面积梗死组(≤3 cm,>1.5 cm)26例],另选取健康体检者50例为对照组。观察组及对照组均进行D-D、CRP、NT-proBNP水平检测。比较观察组及对照组的CRP、D-D、NT-proBNP水平,观察组不同脑梗死面积患者的CRP、D-D、NT-proBNP水平。结果观察组CRP、D-D、NT-proBNP水平均高于对照组,差异具有统计学意义(P<0.05)。观察组中,大面积梗死组的NT-proBNP、D-D、CRP水平分别为(3351.70±940.97)pg/ml、(898.43±323.19)ng/ml、(41.79±11.08)mg/L,中面积梗死组的NT-proBNP、D-D、CRP水平分别为(1338.06±345.23)pg/ml、(573.88±312.67)ng/ml、(32.05±11.77)mg/L,小面积梗死组的NT-proBNP、D-D、CRP水平分别为(447.00±195.72)pg/ml、(334.15±229.81)ng/ml、(18.03±10.14)mg/L。大面积梗死组患者的NT-proBNP、D-D、CRP水平均高于中面积梗死组及小面积梗死组,中面积梗死组患者的NT-proBNP、D-D、CRP水平均高于小面积梗死组,差异具有统计学意义(P<0.05)。结论 D-D、CRP、NT-proBNP在诊断中老年急性脑梗死患者中存在较高的应用价值。
Objective To analyze the diagnostic value of N-terminal pro-B-type natriuretic peptide(NT-proBNP),D-dimer(D-D)and C-reactive protein(CRP)in middle-aged and elderly patients with acute cerebral infarction(ACI).Methods 52 middle-aged and elderly patients with acute cerebral infarction were selected as the observation group[according to diameters of the infarct area,the observation group was divided into large-area infarction group(>5 cm,10 cases),small-area infarction group(≤5 cm and>3 cm,16 cases)and medium-area infarction group(≤3 cm and>1.5 cm,16 cases)],and another 50 healthy subjects were selected as the control group.D-D,CRP and NT-proBNP levels were detected in the observation group and the control group.The levels of CRP,D-D and NT-proBNP in the observation group and the control group were compared,and the levels of CRP,D-D and NT-proBNP in patients with different infarct area in the observation group were compared.Results The levels of CRP,D-D and NT-proBNP in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).In the observation group,the levels of NT-proBNP,D-D and CRP in the large-area infarction group were(3351.70±940.97)pg/ml,(898.43±323.19)ng/ml and(41.79±11.08)mg/L,respectively;the levels of NT-proBNP,D-D and CRP in the medium-area infarction group were(1338.06±345.23)pg/ml,(573.88±312.67)ng/ml and(32.05±11.77)mg/L,respectively;the levels of NT-proBNP,D-D and CRP in small-area infarction group were(447.00±195.72)pg/ml,(334.15±229.81)ng/ml and(18.03±10.14)mg/L,respectively.The levels of NT-proBNP,D-D and CRP in large-area infarction group were higher than those in medium-area infarction group and small-area infarction group;the levels of NT-proBNP,D-D and CRP in medium-area infarction group were higher than those in small-area infarction group;the difference was statistically significant(P<0.05).Conclusion D-D,CRP and NT-proBNP have high application value in the auxiliary diagnosis of acute cerebral infarction in the middle aged and elderly.
作者
张伟
ZHANG Wei(Department of Clinical Laboratory,the First Hospital of Fangshan District,Beijing 102400,China)
出处
《中国实用医药》
2024年第10期81-84,共4页
China Practical Medicine
关键词
D-二聚体
C反应蛋白
氨基末端脑钠肽前体
急性脑梗死
诊断价值
D-dimer
C-reactive protein
N-terminal pro-B-type natriuretic peptide
Acute cerebral infarction
Diagnostic value
