摘要
目的探讨急性脑梗死(ACI)患者血浆细胞游离线粒体DNA(cf-mtDNA)拷贝数与卒中后抑郁(PSD)的关系。方法选取128例ACI患者为研究对象,其中发生PSD 42例,未发生PSD 86例。根据抑郁严重程度,将PSD患者分为轻度组(n=13)、中度组(n=24)和重度组(n=5)。分析血浆cf-mtDNA拷贝数与美国国立卫生院卒中量表(NIHSS)评分及17项汉密尔顿抑郁量表(HAMD-17)评分的相关性。采用多因素Logistic回归分析影响PSD发生的独立因素;采用受试者工作特征曲线(ROC)分析血浆cf-mtDNA拷贝数诊断PSD的价值,计算曲线下面积(AUC)。结果PSD患者血浆cf-mtDNA拷贝数高于非PSD患者(P<0.05)。年龄、高血压、NIHSS评分、cf-mtDNA拷贝数是ACI患者发生PSD的影响因素(P<0.05)。Logistic多因素分析结果显示年龄、NIHSS评分、cf-mtDNA拷贝数是ACI患者发生PSD的独立影响因素(P<0.05)。相关性分析结果显示,cf-mtDNA拷贝数与NIHSS评分、HAMD-17评分均呈正相关(P<0.001)。cf-mtDNA拷贝数诊断PSD的AUC为0.862(P<0.001),灵敏度为87.27%,特异度为71.62%。结论血浆cf-mtDNA拷贝数升高是ACI患者发生PSD的独立影响因素,并且对PSD的诊断有一定价值。
Objective To explore the relationship between plasma cell free mitochondrial DNA(cf-mtDNA)copy number and post stroke depression(PSD)in patients with acute cerebral infarction(ACI).Methods A total of 128 ACI patients were selected as the study subjects,of which 42 had PSD and 86 did not.According to the severity of depression,PSD patients were divided into mild group(n=13),moderate group(n=24),and severe group(n=5).The correlations between plasma cf-mtDNA copy number and scores of National Institutes of Health Stroke Scale(NIHSS)and Hamilton Depression Scale-17 items(HAMD-17)were analyzed.Using multivariate logistic regression analysis to identify independent factors affecting the occurrence of PSD.The diagnostic value of plasma cf-mtDNA copy number for PSD was analyzed through receiver operating characteristic(ROC)curve and to calculate the area under the curve(AUC).Results The copy number of plasma cf-mtDNA in PSD patients was higher than that in non-PSD patients(P<0.05).Age,hypertension,NIHSS score,and cf-mtDNA copy number were influencing factors for the occurrence of PSD in ACI patients(P<0.05).The results of multivariate logistic analysis showed that age,NIHSS score,and cf-mtDNA copy number were independent influencing factors for the occurrence of PSD in ACI patients(P<0.05).The correlation analysis showed that the copy number of cf-mtDNA was positively correlated with NIHSS score and HAMD-17 score(P<0.001).The AUC for cf-mtDNA copy number diagnosing PSD was 0.862(P<0.001),with a sensitivity of 87.27%and a specificity of 71.62%.Conclusion The increase in plasma cf-mtDNA copy number is an independent influencing factor for the occurrence of PSD in ACI patients,and has potential value in the diagnosis of PSD.
作者
董晓梅
耿忠丽
史宝光
施春阳
张欧
DONG Xiaomei;GENG Zhongli;SHI Baoguang(General Hospital of the Northern Theater Command,Shenyang 110015,China)
出处
《精神医学杂志》
2024年第1期10-13,共4页
Journal of Psychiatry
基金
沈阳市科学技术计划项目(编号:21-173-9-76)。
关键词
急性脑梗死
血浆线粒体DNA
卒中后抑郁
诊断标志物
Acute cerebral infarction
Plasma mitochondrial DNA
Post stroke depression
Diagnosis biomarker
