摘要
目的探讨小而密低密度脂蛋白胆固醇(sdLDL-C)/高密度脂蛋白胆固醇(HDL-C)对急性心肌梗死患者介入治疗预后的预测价值。方法回顾性抽取2021年1月至2022年12月南阳市第二人民医院收治的急性心肌梗死患者120例,均接受经皮冠状动脉介入治疗,依据是否发生不良心血管事件分为预后良好组(95例)和预后不良组(25例)。比较两组患者入院时血清总胆固醇、三酰甘油、低密度脂蛋白胆固醇、HDL-C、sdLDL-C、sdLDL-C/HDL-C,分析以上指标与急性心肌梗死患者介入治疗预后的相关性,绘制受试者工作特征曲线,计算曲线下面积(AUC)评估预测价值。结果预后不良组总胆固醇、三酰甘油、低密度脂蛋白胆固醇、sdLDL-C、sdLDL-C/HDL-C高于预后良好组,HDL-C低于预后良好组,差异有统计学意义(P<0.05)。点二列相关性分析结果显示,急性心肌梗死患者介入治疗预后与总胆固醇、三酰甘油、低密度脂蛋白胆固醇、sdLDL-C、sdLDL-C/HDL-C呈正相关(r>0,P<0.05),与HDL-C呈负相关(r<0,P<0.05)。HDL-C、sdLDL-C、sdLDL-C/HDL-C预测急性心肌梗死患者介入治疗预后的AUC分别为0.78、0.77、0.87。结论sdLDL-C/HDL-C与急性心肌梗死患者介入治疗预后密切相关,且其对预测预后不良具有重要价值。
Objective To investigate the predictive value of small dense low density lipoprotein cholesterol(sdLDL-C)/high density lipoprotein cholesterol(HDL-C)for the prognosis of interventional therapy in patients with acute myocardial infarction.Methods A total of 120 patients with acute myocardial infarction admitted to Nanyang Second General Hospital from January 2021 to January 2022 were selected retrospectively.They all received percutaneous coronary intervention,and they were divided into the good prognosis group(95 cases)and the poor prognosis group(25 cases)according to the occurrence of adverse cardiovascular events.The total cholesterol,triglycerides,low-density lipoprotein cholesterol,HDL-C,sdLDL-C,and sdLDL-C/HDL-C of the two groups were compared.The correlation of these indexes with prognosis of interventional treatment in patients with acute myocardial infarction were analyzed,and the area under the receiver operating characteristic curve(AUC)of these indexes were analyzed.Results The total cholesterol,triglycerides,low-density lipoprotein cholesterol,sdLDL-C,and sdLDL-C/HDL-C of the poor prognosis group were higher than those of the good prognosis group,while level of HDL-C of the poor prognosis group was lower than that of the good prognosis group(P<0.05).The results of point-biserial correlation analysis showed that the prognosis of acute myocardial infarction was positively correlated with total cholesterol,triglycerides,low-density lipoprotein cholesterol,sdLDL-C,and sdLDL-C/HDL-C(r>0,P<0.05),and it was negatively correlated with HDL-C(r<0,P<0.05).The AUC of HDL-C,sdLDL-C and sdLDL-C/HDL-C in predicting the prognosis of interventional therapy in patients with acute myocardial infarction were 0.78,0.77 and 0.87,respectively.Conclusions The sdLDL-C/HDL-C is closely related to the prognosis of interventional therapy in patients with acute myocardial infarction,which has important value in predicting the occurrence of poor prognosis.
作者
井河江
张鸿梅
华朋铎
杨楠
Jing Hejiang;Zhang Hongmei;Hua Pengduo;Yang Nan(Department of Cardiovascular Medicine,Nanyang Second General Hospital,Nanyang 473000,China)
出处
《中国实用医刊》
2024年第7期27-30,共4页
Chinese Journal of Practical Medicine
关键词
心肌梗死
小而密低密度脂蛋白胆固醇
高密度脂蛋白胆固醇
介入治疗
预后
Myocardial infarction
Small dense low-density lipoprotein cholesterol
High density lipoprotein cholesterol
Interventional therapy
Prognosis
