摘要
目的探讨艾司西酞普兰联合奥卡西平治疗癫痫合并抑郁的临床效果。方法前瞻性研究。抽取2020年7月至2022年7月于榆林市第四医院治疗的200例癫痫合并抑郁患者,按随机数字表法分为单药组与联合组,每组100例。单药组仅给予艾司西酞普兰治疗,联合组给予艾司西酞普兰联合奥卡西平治疗,两组均持续治疗2个月。比较两组治疗有效率、汉密尔顿抑郁量表(HAMA)评分、汉密尔顿焦虑量表(HAMA)评分、癫痫患者生活质量评估表(QOLIE-31)评分、血清5-羟色胺水平、多巴胺水平、不良反应发生率。结果单药组与联合组患者一般资料比较差异未见统计学意义(P>0.05)。联合组治疗总有效率(96.00%,96/100)高于单药组(87.00%,87/100),P<0.05。治疗后,两组HAMD评分、HAMA评分均下降,QOLIE-31评分提高,且联合组变化幅度大于单药组(P<0.05)。治疗后,两组血清5-羟色胺及多巴胺水平均高于治疗前,且联合组高于单药组(P<0.05)。联合组不良反应发生率(8.00%,8/100)与单药组(12.00%,12/100)比较差异未见统计学意义(P>0.05)。结论艾司西酞普兰联合奥卡西平应用于癫痫合并抑郁患者,可提高治疗有效率,减轻患者抑郁及焦虑,增加血清5-羟色胺及多巴胺水平,且安全性高。
Objective To investigate the clinical efficacy of escitalopram combined with oxcarbazepine in the treatment of patients with epilepsy complicated by depression.Methods A total of 200 patients with epilepsy complicated by depression treated in Fourth Hospital of Yulin from July 2020 to July 2022 were selected for the prospective study,and they were divided into the single drug group and the combined group according to random number table method,with 100 cases in each group.The single drug group was treated with escitalopram,and the combined group was treated with escitalopram combined with oxcarbazepine;bothe groups were treated continuously for 2 months.The effective rate,Hamilton depression scale(HADA)score,Hamilton anxiety scale(HAMA)score,QOLIE-31 score,serum 5-hydroxytryptamine and dopamine levels and the incidence of adverse reactions were compared between the two groups.Results There was no significant difference in general data between the single drug group and the combined group(P>0.05).The total effective rate of the combined group(96.00%,96/100)was higher than that of the single drug group(87.00%,87/100),P<0.05.After treatment,the scores of HAMD and HAMA of the two groups decreased,and the score QOLIE-31 increased in both groups,moreover,the amplitude of changes in the combined group was greater compared with the single drug group(P<0.05).After treatment,the levels of serum 5-hydroxytryptamine and dopamine in both groups increasedm,and the combined group had higher levels than the single drug group(P<0.05).There was no significant difference in the incidence of adverse reactions between the combined group(8.00%,8/100)and the single drug group(12.00%,12/100),P>0.05.Conclusions Escitalopram combined with oxcarbazepine is effective and safe in the treatment of patients with epilepsy complicated by depression.It can improve the treatment efficacy,alleviate depression and anxiety,increase levels of serum 5-hydroxytryptamine and dopamine,with great safety.
作者
慕鹏莺
惠玲利
Mu Pengying;Hui Lingli(Department of Neurology,Fourth Hospital of Yulin,Yulin 719000,China;Department of Sleep Psychology,Fourth Hospital of Yulin,Yulin 719000,China)
出处
《中国实用医刊》
2024年第6期105-108,共4页
Chinese Journal of Practical Medicine
