摘要
目的探讨消化性溃疡(PU)患者采用坐珠达西治疗的效果。方法将广昌县人民医院2022年1月-2023年1月收治的80例PU患者随机分为两组,每组各40例,对照组采用常规西医治疗,观察组在对照组基础上加用坐珠达西治疗,均治疗1个月。比较两组治疗效果、症状改善时间、炎症指标及不良反应。结果与对照组治疗总有效率72.50%(29/40)比较,观察组治疗总有效率95.00%(38/40)更高(P<0.05);观察组反酸、嗳气、腹痛腹胀、烧心改善时间及溃疡愈合时间均比对照组短(P<0.05);治疗后,两组血清C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、白细胞介素4(IL4)水平均降低,且观察组更低(P<0.05);观察组不良反应发生率12.50%(5/40)与对照组7.50%(3/40)比较,无统计学差异(P>0.05)。结论PU患者采用坐珠达西治疗效果满意,可减轻炎症反应,缩短溃疡愈合时间,且安全性好。
Objective To investigate the effect of Zuozhu Daxi in the treatment of patients with peptic ulcer(PU).Methods 80 PU patients admitted to the hospital from January 2022 to January 2023 were randomly divided into two groups,40 cases in each group.The control group was treated with conventional western medicine.Based on this,the observation group was treated with Zuozhu Daxi for 1 month.The therapeutic effect,symptom improvement time,inflammatory indexes and adverse reactions were compared between the two groups.Results Compared with the control group,the total effective rate was 72.50%(29/40),and the total effective rate in the observation group was 95.00%(38/40)higher(P<0.05).The improvement time of acid regurgitation,belching,abdominal pain and distension,heartburn and ulcer healing time in observation group were shorter than those in control group(P<0.05).After treatment,the levels of serum C-reactive protein(CRP),tumor necrosis factorα(TNF-α),interleukin-6(IL-6)and interleukin-4(IL-4)in 2 groups were decreased,and the levels were lower in observation group(P<0.05).The incidence of adverse reactions in the observation group was 12.50%(5/40)compared with 7.50%(3/40)in the control group,and there was no statistical difference(P>0.05).Conclusion The treatment effect of Zuozhu Daxi in PU patients is satisfactory,which can reduce inflammation,shorten ulcer healing time,and has good safety.
作者
刘艳花
唐广平
李添
Liu Yanhua;Tang Guangping;Li Tian(Department of Pharmacy,Guangchang County People's Hospital,Fuzhou,Jiangxi 344900,China)
出处
《首都食品与医药》
2024年第10期157-160,共4页
Capital Food Medicine
