摘要
目的:探究地佐辛在高龄髋部手术患者中的应用效果及对谵妄相关指标的影响。方法:选取2021年6月—2023年6月南平市建阳第一医院收治的80例高龄髋部手术患者。对照组给予腰硬联合麻醉,观察组在对照组的基础上给予地佐辛。比较两组不良反应,术后2 h、6 h及12 h疼痛程度,术后1 h、2 h及6 h镇静情况,谵妄发生情况及谵妄相关血液指标。结果:观察组不良反应发生率显著低于对照组,差异有统计学意义(P<0.05)。观察组术后2 h、6 h及12 h的静息及活动视觉模拟评分法(VAS)评分均显著低于对照组,差异有统计学意义(P<0.05)。观察组术后1 h、2 h及6 h的警觉/镇静观察评分(OAA/S)评分显著高于对照组,差异有统计学意义(P<0.05)。观察组谵妄发生率显著低于对照组,差异有统计学意义(P<0.05)。术后24 h及72 h,观察组神经元特异性烯醇化酶(NSE)、中枢神经特异性蛋白(S100-β)及白细胞介素-6(IL-6)水平均显著低于对照组,差异有统计学意义(P<0.05)。结论:地佐辛在高龄髋部手术患者中的应用效果较好,更有助于控制谵妄发生率及其相关血液指标的表达。
Objective:To investigate the application effect of Dezocine in advanced age patients with hip surgery and its influence for delirium related indexes.Method:A total of 80 advanced age patients with hip surgery admitted to Nanping Jianyang First Hospital from June 2021 to June 2023 were selected.The control group was given combined epidural anesthesia,and the observation group was given Dezocine on the basis of the control group.The adverse reactions,pain degree at 2 h,6 h and 12 h after surgery,sedation condition at 1 h,2 h and 6 h after surgery,delirium occurrence condition and delirium-related blood indexes were compared between the two groups.Result:The incidence of adverse reactions in observation group was significantly lower than that in control group,and the difference was statistically significant(P<0.05).The resting and active visual analogue scale(VAS)scores of the observation group at 2 h,6 h and 12 h after surgery were significantly lower than those of the control group,and the differences were statistically significant(P<0.05).The observer's assessment of alterness/sedation(OAA/S)scores of the observation group at 1 h,2 h and 6 h after surgery were significantly higher than those of the control group,and the differences were statistically significant(P<0.05).The incidence of delirium in the observation group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).The levels of neuron-specific enolase(NSE),central nervous specific protein(S100-β)and interleukin-6(IL-6)in the observation group were significant lower than those in the control group at 24 h and 72 h after surgery,and the differences were statistically significant(P<0.05).Conclusion:The application effect of Dezocine in advanced age patients with hip surgery is better,and it is helpful to the control the delirium occurrence and the related blood indexes expression of patients.
作者
吴锦红
WU Jinhong(Nanping Jianyang First Hospital,Nanping 354200,China)
出处
《中外医学研究》
2024年第14期107-110,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
地佐辛
高龄患者
髋部手术
谵妄
Dezocine
Advanced age patients
Hip surgery
Delirium
