摘要
目的:探讨养血祛风方对维持性血液透析皮肤瘙痒患者瘙痒程度及瘙痒介质血液生化指标的影响。方法:将106例2020年6月~2023年6月六安市中医院收治的维持性血液透析皮肤瘙痒患者随机纳入对照组(53例)和试验组(53例),分组方法选择随机数字表法。对照组给予氯雷他定片进行治疗,试验组在对照组的基础上给予养血祛风方进行治疗,两组均持续治疗4周。比较两组治疗4周后的疗效,治疗前、治疗4周后的瘙痒、疼痛程度、睡眠质量、炎症指标、瘙痒介质血液生化指标及治疗期间的不良反应发生情况。结果:治疗4周后,试验组总有效率为92.45%,高于对照组的77.36%(P<0.05)。治疗4周后,两组改良Duo评分、视觉模拟评分(VAS)评分、匹兹堡睡眠质量指数问卷(PSQI)评分、血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、全血甲状旁腺激素(PTH)、尿素氮(BUN)、β2微球蛋白(β2-MG)、血磷(P)、血钙(Ca)水平与治疗前比较降低,试验组低于对照组(P<0.05)。治疗期间,试验组不良反应总发生率为3.77%,低于对照组的15.09%(P<0.05)。结论:养血祛风方可有效调节维持性血液透析皮肤瘙痒患者瘙痒介质血液生化指标及炎症指水平,缓解机体炎症,改善患者瘙痒、疼痛程度及睡眠质量,进而有利于提高疗效,且具有较好的安全性。
Objective To investigate the effect of Yangxue Qufeng formula on the degree of itch and blood biochemical indicators of itch media in maintenance hemodialysis patients with skin itch.Methods 106patients with maintenance hemodialysis skin itch admitted to Lu'an traditional Chinese medicine hospital from June 2020to June 2023were randomly divided into the control group(53cases)and the experimental group(53cases),and the grouping method was selected using a random number table method.The control group was treated with loratadine tablets,while the experimental group was treated with Yangxue Qufeng formula on the basis of the control group.Both groups continued to receive treatment for 4weeks.The efficacy after 4weeks of treatment,levels of itch,pain,sleep quality,inflammation indicators,itching mediator blood biochemical indicators before and after 4weeks of treatment,and the occurrence of adverse reactions during the treatment period of the two groups were compared.Results After 4weeks of treatment,the total effective rate in the experimental group was 92.45%,which was higher than 77.36%in the control group(P<0.05).After 4weeks of treatment,the scores of Duo score,visual analogue score(VAS),pittsburgh sleep quality index(PSQI),serum levels of C-reactive protein(CRP),interleukin-6(IL-6),interleukin-1β(IL-1β),whole blood parathyroid hormone(PTH),urea nitrogen(BUN)β2microglobulin(β2-MG),phosphorus(P),calcium(Ca)decreased compared to before treatment,and the experimental group was lower than the control group(P<0.05).During the treatment period,the total incidence of adverse reactions in the experimental group was 3.77%,lower than the 15.09%in the control group(P<0.05).Conclusion The Yangxue Qufeng formula could effectively regulate the levels of itching mediators,blood biochemical indicators,and inflammatory index in maintenance hemodialysis patients with skin itching,alleviate inflammation in the body,improve the degree of itching,pain,and sleep quality of patients,thereby improving the therapeutic effect and had good safety.
作者
张小敏
王晓星
束永兵
刘贤亮
周舒梅
ZHANG Xiaomin;WANG Xiaoxing;SHU Yongbing(Department of Nephrology,Lu'an Traditional Chinese Medicine Hospital,Lu'an Anhui 237000,China)
出处
《四川中医》
2024年第4期171-175,共5页
Journal of Sichuan of Traditional Chinese Medicine
基金
2021年安徽省重点研究与开发计划(第一批)立项项目(编号:202104j07020014)。
关键词
维持性血液透析
皮肤瘙痒
养血祛风方
氯雷他定片
瘙痒程度
瘙痒介质
生化指标
Maintenance hemodialysis
Skin itch
Yangxue Qufeng formula
Loratadine tablets
The degree of itch
Itchy media
Biochemical indicators
