摘要
苦白蹄来源于药用拟层孔菌Fomitopsis officinalis的干燥子实体,具有抑菌消炎、止咳平喘、祛风除湿、消肿止痛和抗癌的功效。对苦白蹄的化学成分(包括三萜酸类、甾体类、倍半萜类、多糖类)及其提取部位和有效成分对肝癌、乳腺癌、肺癌、胃癌等肿瘤细胞系的抑制作用进行归纳和总结,以期为苦白蹄的深入研究和进一步开发利用提供思路与依据。苦白蹄提取部位和有效成分抗肿瘤具有多成分、多靶点的特点,其作用机制包括抑制肿瘤细胞增殖、诱导其凋亡、抑制肿瘤细胞迁移和侵袭、增强机体免疫及抑制肿瘤血管生成。
Agarikon is the dried fruiting body of Fomitopsis officinalis,which has the functions of inhibiting bacteria and reducing inflammation,relieving cough and asthma,dispelling wind and removing dampness,relieving swelling and pain,and anticancer.The chemical components(including triterpenic acid,steroids,sesquiterpenoids and polysaccharides)and their inhibitory effects on liver cancer,breast cancer,lung cancer and gastric cancer were summarized.This paper provides some useful ideas and directions for the further research and development of Fomitopsis officinalis.The extraction sites and active components of Fomitopsis officinalis have the characteristics of multi-components and multi-targets for anti-tumor.The mechanism of action includes inhibition of tumor cell proliferation,induction of apoptosis,inhibition of tumor cell migration and invasion,enhancement of immunity and inhibition of tumor angiogenesis.
作者
王鑫
关雪
陈大忠
WANG Xin;GUAN Xue;CHEN Dazhong(Heilongjiang University of Traditional Chinese Medicine,Harbin 150000,China)
出处
《药物评价研究》
CAS
北大核心
2024年第4期897-903,共7页
Drug Evaluation Research
基金
黑龙江省应用技术研究与开发计划项目(GA19C009)。
关键词
苦白蹄
药用拟层孔菌
抗肿瘤
肝癌
乳腺癌
肺癌
胃癌
Agarikon
Fomitopsis officinalis(Vill.ex Fr.)Bond.et Sing.
antitumor
liver cancer
breast cancer
lung cancer
gastric cancer
