摘要
目的分析重度有机磷中毒患者的治疗中采取急诊血液灌流的临床效果。方法选取2022年1月—2023年12月单县中心医院收治的80例重度有机磷重度患者为研究对象,随机数表法分为两组,各40例。对照组实施常规治疗,研究组实施常规治疗+采取血液灌流治疗,对比两组胆碱酯酶变化、炎性因子水平、临床指标转归情况、并发症发生率。结果治疗后6、24、36 h,研究组胆碱酯酶水平高于对照组,差异有统计学意义(P均<0.05)。研究组白细胞介素-6、白细胞介素-8、白细胞介素-1β、肿瘤坏死因子-α水平均低于对照组,差异有统计学意义(P均<0.05)。研究组胆碱酯酶活性恢复时间、恢复清醒时间、阿托品用量及住院时间均优于对照组,差异有统计学意义(P均<0.05)。研究组并发症发生率为10.00%低于对照组的30.00%,差异有统计学意义(χ^(2)=5.000,P<0.05)。结论在重度有机磷中毒患者的治疗中采用血液灌流效果好,具有临床应用价值。
Objective To analyze the clinical effect of emergency hemoperfusion in the treatment of patients with severe organophosphorus poisoning.Methods Eighty patients with severe organophosphorus treated in Shanxian Central Hospital from January 2022 to December 2023 were selected as the study objects,and they were divided into two groups with 40 cases each by random number table method.The control group received conventional treatment,and the study group received conventional treatment+hemoperfusion treatment.The changes of cholinesterase,the level of inflammatory factors,the outcome of clinical indicators and the incidence of complications were compared between the two groups.Results At 6,24 and 36 hours after treatment,the cholinesterase level of the study group was higher than that of the control group,and the differences were statistically significant(all P<0.05).The levels of interleukin-6,interleukin-8,interleukin-1βand tumor necrosis factor-αin the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The recovery time of cholinesterase activity,recovery time of wakefulness,dosage of atropine and hospitalization time in the study group were better than those in the control group,and the differences were statistically significant(all P<0.05).The incidence of complications in the study group was 10.00%lower than that in the control group(30.00%),and the difference was statistically significant(χ^(2)=5.000,P<0.05).Conclusion In the treatment of patients with severe organophosphorus poisoning,hemoperfusion has good effect and has clinical application value.
作者
赵磊
于霜
刘庆福
ZHAO Lei;YU Shuang;LIU Qingfu(Department of Emergency,Shanxian Central Hospital,Heze,Shandong Province,274300 China)
出处
《系统医学》
2024年第9期72-75,共4页
Systems Medicine
关键词
重度有机磷中毒
血液灌流
炎性因子
Severe organophosphorus poisoning
Hemoperfusion
Inflammatory factor
