摘要
目的 探究检测血清D-二聚体(D-D)、糖化血清蛋白(GSP)、糖化血红蛋白(HbA1c)表达水平在妊娠糖尿病中的临床意义。方法 选取2020年1月至2022年12月于郑州大学第二附属医院就诊117例妊娠糖尿病患者为研究组,同期选择117例体检健康孕妇作为对照组进行研究,比较两组血清D-D、GSP、HbA1c水平及稳态模型胰岛素抵抗指数(HOMA-IR),采用Pearson分析入院时血清D-D、GSP、HbA1c水平与HOMA-IR相关性,受试者工作特征(ROC)曲线分析血清D-D、GSP联合HbA1c水平检测对妊娠糖尿病病情程度的评估价值。结果 与对照组相比,研究组血清D-D、GSP、HbA1c水平及HOMA-IR均升高(P<0.05)。不同病情程度孕妇的血清D-D、GSP、HbA1c水平及HOMA-IR指数比较:重度>中度>轻度(P<0.05)。血清D-D、GSP、HbA1c水平与HOMA-IR均呈正相关(r=0.671、0.715、0.696,P<0.05)。产检时血清D-D、GSP、HbA1c水平联合诊断中度、重度妊娠糖尿病的曲线下面积(AUC)分别为0.859、0.873,最佳敏感度分别为95.64%、96.30%,特异度分别为76.12%、78.26%。结论 血清D-D、GSP、HbA1c水平联合检测可为临床评估妊娠糖尿病病情程度提供可靠参考依据。
Objective To explore the clinical significance of serum D-dimmer(D-D),glycosylated serum protein(GSP)and glycosylated hemoglobin A1c(HbA1c)expression levels in gestational diabetes mellitus.Methods A total of 117 patients with gestational diabetes mellitus admitted to the Second Affiliated Hospital of Zhengzhou University from January 2020 to December 2022 were selected as the study group,and 117 healthy pregnant women were selected as the control group during the same period.Serum D-D,GSP,HbA1c and homeostasis model assessment-insulin resistance index(HOMA-IR)of the two groups were compared.Pearson was used to analyze the correlation between serum D-D,GSP,HbA1c levels and HOMA-IR at admission,and receiver operating characteristic curve was used to analyze the value of serum D-D,GSP combined with HbA1c levels in evaluating the severity of gestational diabetes.Results Compared with the control group,serum D-D,GSP,HbA1c levels and HOMA-IR levels in the study group were increased(P<0.05).Serum D-D,GSP,HbA1c levels and HOMA-IR index of pregnant women with different disease levels were compared:severe>moderate>mild(P<0.05).Serum D-D,GSP,HbA1c levels were positively correlated with HOMA-IR(r=0.671,0.715,0.696,P<0.05).The area under the curve of serum D-D,GSP and HbA1c levels in the combined diagnosis of moderate and severe gestational diabetes mellitus was 0.859 and 0.873,respectively.The best sensitivity was 95.64%and 96.30%,and the specificity was 76.12%and 78.26%,respectively.Conclusion The combined detection of serum D-D,GSP and HbA1c levels can provide a reliable reference for clinical evaluation of gestational diabetes mellitus.
作者
高萃
崔金全
邵文嘉
GAO Cui;CUI Jinquan;SHAO Wenjia(Department of Gynecology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China)
出处
《河南医学研究》
CAS
2024年第11期1997-2001,共5页
Henan Medical Research
