摘要
目的:探讨近12年来中药治疗早期股骨头坏死的用药组方规律,并综述目前相关中药治疗早期股骨头坏死的国内外研究进展,为临床应用中药治疗早期股骨头坏死和进一步的实验研究提供参考。方法:检索2010年1月1日至2022年10月15日中国期刊全文数据库(CNKI)、万方数据知识服务平台(Wangfang Data)、维普中文期刊服务平台(VIP)和PubMed收录的关于中药治疗早期股骨头坏死的临床研究文献,提取中药处方,建立中药处方数据库,运用Microsoft Excel 2010、SPSS Statistics 19和SPSS Modeler 15.0,采用描述性分析、聚类分析和关联规则分析等数据挖掘方法进行分析。结果:在42条中药处方中共出现了166种中药,总频次为591次;得到5个有效聚类群,其中当归和牛膝各为一个聚类,甘草、黄芪、川芎、红花、熟地黄、丹参、骨碎补、杜仲和续断为一个聚类,鹿角胶、乳香、白芍、鸡血藤和淫羊藿为一个聚类,其余20味药物为一个聚类;得到10个高价值中药组合,分别为乳香-没药、鸡血藤-威灵仙、白芍-柴胡、鸡血藤-威灵仙-白芍、鸡血藤-生地黄-桂枝、鹿角胶-菟丝子-赤芍、补骨脂-菟丝子-桂枝、乳香-没药-补骨脂、乳香-没药-淫羊藿和乳香-没药-鹿角胶。结论:近10年来中药治疗早期股骨头坏死主要选用补虚药和活血化瘀药,高价值对症治疗中药组合较多,且均符合早期股骨头坏死的常见症状,同时一些单味中药值得进一步的基础研究。
ObjectiveObjective:On the basis of discussing the prescription rules of traditional Chinese medicine in treating early avascular necrosis of the femo‐ral head in the past 12 years,this paper further summarizes the current research progress in the treatment of early avascular necrosis of the femoral head with traditional Chinese medicine at home and abroad,and provides a reference for clinical application of traditional Chinese medicine in the treatment of early avascular necrosis of the femoral head and further experimental research.MethodsMethods:Search the clinical research literature on the treatment of early avascular necrosis of the femoral head by traditional Chinese medicine included in CNKI,Wanfang Data,Vip and PubMed from January 1,2010 to October 15,2022,extract the prescription of traditional Chinese medicine,establish the Excel prescription database of traditional Chinese medicine,use Microsoft Excel 2010,SPSS Statistics 19 and SPSS Modeler 15.0,Data mining methods such as descriptive analysis,cluster analysis and association rule analysis are used for analysis.ResultsResults:A total of 166 kinds of traditional Chinese Herbs appeared in 42 traditional Chi‐nese medicine prescriptions,with a total frequency of 591 times;Five effective clusters were obtained,of which Danggui and Niuxi were one cluster respectively,Gancao,Hangqi,Chuanxiong,Honghua,Shudihuang,Dashen,Gusuibu,Duzhong and Xuduan were one cluster,Lujiaojiao,Ruxiang,Baishao,Jixueteng and Yinyanghuo were one cluster,and the other 20 herbs were one cluster.A total of 10 high-value traditional Chinese medicine combinations were obtained in this study,which were Ruxiang-Moyao,Jixueteng-Weilingxian,Baishao-Chaihu,Jixueteng-Weilingxian-Baishao,Jixueteng-Shengdihuang-Guizhi,Lujiaojiao-TusiziChishao,Buguzhi-Tusizi-Guizhi,Ruxiang-Moyao-Buguzhi,Ruxiang-Moyao-Yinyanghuo and Ruxiang-Moyao-Lujiaojiao.ConclusionConclusion:In the past 10 years,traditional Chinese medicine for the treatment of early avascular necrosis of the femo‐ral head has mainly used drugs for tonifying deficiency and promoting blood circulation and removing blood stasis.There are many combinations of high-value symptomatic treatment of traditional Chinese medicine,which are consistent with the common symptoms of early avascular necrosis of the femoral head.At the same time,some single traditional Chinese medicine is worthy of further basic research.
作者
钱朝良
邢涛
李向洲
韩李霞
杨博
QIAN Chao-liang;XING Tao;LI Xiang-zhou;HAN Li-xia;YANG Bo(Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu 730000;Gansu Hospital of traditional Chinese Medicine,Lanzhou,Gansu 730000)
出处
《中医康复》
2024年第8期27-32,共6页
Traditional Chinese Medicine Rehabilitation
基金
甘肃省自然科学基金(22JR5RA628)。
关键词
股骨头坏死
早期
中药
数据挖掘
组方规律
femoral head necrosis
early stage
Chinese herbs
data mining
prescription law
