摘要
目的探讨外周血系统免疫炎症指数(SII)、中性粒细胞计数与淋巴细胞计数比值(NLR)及血小板计数与淋巴细胞计数比值(PLR)对结直肠癌的诊断价值及与预后的关系。方法选取150例结直肠癌患者(结直肠癌组)和150例体检的健康者(对照组)为研究对象,对两组临床资料进行回顾性分析。检测并比较两组术前外周血SII、NLR及PLR水平,运用受试者工作特征曲线(ROC)分析SII、NLR及PLR对结直肠癌的诊断效能,分析结直肠癌组不同外周血SII、NLR水平患者的临床病理特征。结果结直肠癌组NLR、SII、PLR水平分别为(3.17±1.46)、(912.49±749.34)、(318.41±319.02),高于对照组的(1.93±0.38)、(406.37±193.2)、(41.37±51.36),差异有统计学意义(P<0.05)。SII、NLR、PLR单独诊断及SII+NLR+PLR联合诊断结直肠癌的曲线下面积(AUC)分别为0.785、0.837、0.847、0.872,灵敏度分别为63.28%、65.31%、77.91%、87.40%,特异度分别为86.42%、85.43%、80.00%、77.90%。低SII组与高SII组、低NLR组与高NLR组患者病理组织类型、淋巴结转移情况比较,差异有统计学意义(P<0.05);低SII组与高SII组、低NLR组与高NLR组患者年龄比较,差异无统计学意义(P>0.05)。结论SII、NLR和PLR是结直肠癌的预测指标,三者联合诊断的价值更高;高SII和高NLR是结直肠癌淋巴结转移的危险因素,具有一定的临床指导意义。
Objective To explore the diagnostic value of peripheral blood systemic immuneinflammation index(SII),neutrophil-to-lymphocyte ratio(NLR)and platelet to lymphocyte ratio(PLR)for colorectal cancer and its correlation with prognosis.Methods A total of 150 cases of colorectal cancer patients(colorectal cancer group),and 150 healthy individuals(the control group)were selected for study,and the clinical data of the two groups was retrospectively analyzed.The preoperative levels of SII,NLR and PLR in peripheral blood of the two groups were detected and compared.The diagnostic efficiency of SII,NLR and PLR in colorectal cancer patients was analyzed by receiver operating characteristic(ROC)curve,and the clinicopathological characteristics of patients with different levels of SII and NLR in peripheral blood of colorectal cancer group were analyzed.Results The levels of NLR,SII and PLR in colorectal cancer group were(3.17±1.46),(912.49±749.34)and(318.41±319.02),which were higher than(1.93±0.38),(406.37±193.2)and(41.37±51.36)in control group.The difference was statistically significant(P<0.05).The area under the curve(AUC)of SII,NLR and PLR alone and SII+NLR+PLR combined diagnosis of colorectal cancer were 0.785,0.837,0.847 and 0.872,the sensitivity were 63.28%,65.31%,77.91%and 87.40%,and the specificity were 86.42%,85.43%,80.0%and 77.90%.The pathological tissue types and lymph node metastasis were compared between low SII group and high SII group,and between low NLR group and high NLR group,and the difference was statistically significant(P<0.05).There was no significant difference in age between low SII group and high SII group,and between low NLR group and high NLR group(P>0.05).Conclusion SII,NLR,and PLR are predictive indicators for colorectal cancer,and the combined diagnosis of the three is of higher value;high SII and high PLR are risk factors for lymph node metastasis of colorectal cancer,and have certain clinical guiding significance.
作者
吴雪
WU Xue(Department of Gastroenterology/Pediatric Surgery,Baise People's Hospital,Baise 533000,China)
出处
《中国实用医药》
2024年第11期82-85,共4页
China Practical Medicine
基金
百色市科学研究与技术开发计划(项目编号:百科20232066)。
