摘要
目的:探究苏子降气汤加减辅助噻托溴铵奥达特罗治疗慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)的作用。方法:选取2021年1月至2023年2月期间本院收治的94例COPD患者作为研究对象。随机将患者分为观察组和对照组,每组各47例。对照组接受噻托溴铵奥达特罗等治疗;观察组在对照组治疗基础上联合苏子降气汤加减治疗,两组均连续治疗1 m。治疗1 m后观察两组的疗效,分析并比较两组治疗前后肺功能指标(第一秒用力呼气容积(First expiratory volume in one second,FEV1)、用力肺活量(Forced vital capacity,FVC))水平、血清炎症介质白细胞介素-6(interleukin 6,IL-6)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)以及不良反应。结果:治疗后,观察组治疗总有效率显著高于对照组(P<0.05);两组的FEV1、FVC水平均较治疗前显著升高,且观察组的FEV1、FVC水平均显著高于对照组(P<0.05);两组的血清IL-6、TNF-α水平均较治疗前显著降低,且观察组的血清IL-6、TNF-α水平均显著低于对照组(P<0.05)。两组治疗过程中均未出现明显不良反应(P>0.05)。结论:苏子降气汤加减辅助噻托溴铵奥达特罗治疗COPD,能提高疗效,改善患者肺功能,抑制炎症反应,且安全性较高。
Objective:To investigate the effect of Suzi Jiangqi Decoction combined with tiotropium bromide and odatterol in the treatment of Chronic obstructive pulmonary disease(COPD).Methods:94 patients with COPD admitted to our hospital from January 2021 to February 2023 were selected as the study objects.Patients were randomly divided into observation group and control group,with 47 cases in each group.The control group received tiotropium bromide and odatterol treatment.The observation group was treated with Suzi Jiangqi Decoction based on the control group,and both groups were treated continuously for 1 month.The efficacy,lung function(first expiratory volume in one second(FEV1),forced vital capacity(FVC)),serum inflammatory mediators’interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and adverse reactions were analyzed and compared between the two groups.Results:After treatment,the total effective rate of observation group was significantly higher than that of control group(P<0.05).After treatment,the levels of FEV1 and FVC in both groups were significantly higher than before treatment,and the levels of FEV1 and FVC in observation group were significantly higher than those in control group(P<0.05).After treatment,the serum levels of IL-6 and TNF-αin 2 groups were significantly lower than before treatment,and the serum levels of IL-6 and TNF-αin observation group were significantly lower than those in control group(P<0.05).There were no obvious adverse reactions during treatment in both groups(P>0.05).Conclusion:Tiotropium bromide and odatterol combined with Suzi Jiangqi Decoction in the treatment of COPD can improve the curative effect,improve lung function,inhibit inflammation,and have high safety.
作者
吴宏凯
Wu Hong-kai(Department of Internal Medicine,Tongbai People's Hospital,Nanyang 474750,Henan,China)
出处
《四川生理科学杂志》
2024年第6期1279-1281,1332,共4页
Sichuan Journal of Physiological Sciences
关键词
慢性阻塞性肺疾病
噻托溴铵奥达特罗
苏子降气汤
肺功能
炎症介质
Chronic obstructive pulmonary disease
Tiotropium bromide odatterol
Suzi Jiangqi Decoction
Lung function
Inflammatory mediators
