摘要
“气滞血瘀”是脊髓损伤重要的中医病机理论,其科学内涵有待进一步阐释。铁死亡作为脊髓损伤重要的病理,其分子生物学和病理学或许与“气滞血瘀”病机理论有密切相关性。从铁死亡的调控机制入手,揭示活血化瘀中药治疗脊髓损伤的分子机制,为中医药治疗脊髓损伤提供分子生物学依据,丰富中医药现代化的研究思路和手段。
Qi stagnation and blood stasis is a major TCM pathogenesis theory of spinal cord injury,and its scientific connotation remains to be explained.Ferroptosis is a key pathological mechanism of spinal cord injury,and its molecular biological basis and pathological process may be closely related to the pathogenesis theory of qi stagnation and blood stasis.Considering the regulatory mechanism of ferroptosis,this paper introduces the molecular mechanism of blood-activating and stasis-resolving Chinese medicines in treating spinal cord injury,aiming to provide molecular evidence for the TCM treatment of spinal cord injury and enrich the research ideas and means for the modernization of TCM.
作者
范筱
徐立柱
陶经纬
劳克诚
戴世友
穆晓红
FAN Xiao;XU Lizhu;TAO Jingwei;LAO Kecheng;DAI Shiyou;MU Xiaohong(Qingdao Municipal Hospital,Qingdao 266011,China;Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《世界中医药》
CAS
北大核心
2024年第8期1188-1191,共4页
World Chinese Medicine
基金
国家自然科学基金项目(82205149)
中国博士后基金项目(2022M710472)。
关键词
脊髓损伤
气滞血瘀
证候
瘀血
生物学基础
病理生理
铁死亡
Spinal cord injury
Qi stagnation and blood stasis
Syndrome
Blood stasis
Biological basis
Pathophysiology
Fer-roptosis
