摘要
目的探讨盐酸奥洛他定片联合注射用复方甘草酸苷及糠酸莫米松乳膏治疗过敏性皮炎的临床效果。方法选取2022年1月-2023年3月期间收治的60例过敏性皮炎患者作为研究对象,依据治疗方法不同将其分为对照组(n=30,注射用复方甘草酸苷及糠酸莫米松乳膏治疗)和观察组(n=30,盐酸奥洛他定片口服联合注射用复方甘草酸苷及糠酸莫米松乳膏治疗)。对比两组临床疗效、皮损和瘙痒程度、血清相关因子、免疫功能以及不良反应。结果观察组治疗后临床疗效高于对照组(P<0.05)。治疗后观察组EASI评分低于对照组(P<0.05)。治疗后,观察组血清IL-18、INF-γ水平显著高于对照组,EBV水平显著低于对照组(P<0.05);治疗后,观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)值均显著低于对照组,CD8^(+)值高于对照组(P<0.05)。两组不良反应无明显差异(P>0.05)。结论盐酸奥洛他定片联合注射用复方甘草酸苷及糠酸莫米松乳膏治疗更有利于改善过敏性皮炎患者血清相关因子及免疫功能,可更好地改善患者临床症状,减轻皮损程度,临床疗效更佳。
Objective To explore the clinical efficacy of the combination of Olotadine Hydrochloride Tablets and Compound Glycyrrhizic Acid Glycyrrhizin and Momoxone Furoate Cream for the treatment of allergic dermatitis.Method Sixty patients with allergic dermatitis from January 2022 to March 2023 were selected as the study subjects.According to different treatment methods,they were divided into a control group(n=30,treated with Compound Glycyrrhizic Acid Glycoside and Momexone Furoate Cream)and an observation group(n=30,treated with oral combination of Olotadine Hydrochloride Tablets and Injection of Compound Glycyrrhizic Acid Glycoside and Momexone Furoate Cream).Compare the clinical efficacy,degree of skin lesions and itching,serum related factors,immune function,and adverse reactions between two groups.Results The clinical efficacy of the observation group after treatment was higher than that of the control group(P<0.05).After treatment,the EASI score in the observation group was lower than that in the control group(P<0.05).After treatment,the levels of the serum IL-18 and INF-γin the observation group was significantly higher than the control group,and the EBV level was significantly lower than the control group(P<0.05);after treatment,the CD3^(+),CD4^(+),CD4^(+)/CD8^(+) values in the observation group were significantly lower than those in the control group,and the CD8^(+) values were higher than those in the control group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion The combination of Olotadine Hydrochloride Tablets and Compound Glycyrrhizic Acid Glycyrrhizin and Momoxone Furoate Cream for Injection is more beneficial for improving serum related factors and immune function in patients with allergic dermatitis.It can better improve clinical symptoms,reduce the degree of skin lesions,and have better clinical efficacy.
作者
胡均
胡振明
沈福东
Hu Jun;Hu Zhenming;Shen Fudong(Dermatology Department of Shanggao County Traditional Chinese Medicine Hospital,Yichun,Jiangxi 336400,China)
出处
《首都食品与医药》
2024年第11期88-90,共3页
Capital Food Medicine
基金
宜春市指导性科技计划(2023ZDJH2989)。
关键词
盐酸奥洛他定片
注射用复方甘草酸苷
糠酸莫米松乳膏
过敏性皮炎
临床研究
Olotadine Hydrochloride Tablets
Compound Glycyrrhetinic Acid Glycoside for Injection
Momoxone Furoate Cream
Allergic dermatitis
Clinical research
