摘要
糖尿病周围神经病变(Diabetic Peripheral Neuropathy,DPN)是指糖尿病患者有与周围神经功能障碍相关的症状或体征,不包括其他疾病因素的影响。本病主要表现为双侧肢体对称性麻木、疼痛与一些感觉的异常,是糖尿病重要的并发症之一,而且使得糖尿病足的发病风险增加,成为糖尿病患者生活质量大大降低和劳动力丧失的重要原因之一。目前西医对本病的治疗以预防和控制病程进展为主,短期内不适症状会有比较明显的改善,但追踪发现,远期治疗效果仍然十分有限。随着中医药的发展,中医药在医学领域的优势逐渐凸显,所以近些年来越来越多的目光聚集到中医药治疗DPN的药理研究上来。查阅众多文献以及临床资料可以发现,不管是组方或是单味中药,在治疗DPN的中药分析归纳中,补气类、活血化瘀类中药使用频率较高,所以文章从现有临床用药研究中选择出黄芪、牛膝、鸡血藤这一角药,从其药理学方面论述其对DPN的治疗可行性、优势及研究进展。本角药配伍从疾病的病机出发,不仅致力于缓解患者的临床症状,而且把握了疾病的根本病机,阴虚为本,瘀血为标,标本兼治,不仅在理论上具有可行性,而且在临床中使用广泛,取得了良好的效果,为临床治疗DPN提供参考。
Diabetic peripheral neuropathy(DPN)is defined as the presence of signs or symptoms associated with peripheral nerve dysfunction in patients with diabetes,excluding factors from other diseases.It mainly manifests as bilateral symmetrical numbness and pain with some sensory abnormalities in the limbs.It is one of the important complications of diabetes,makes the risk of developing diabetic foot increase,and becomes one of the important reasons for greatly reducing the quality of life and loss of labor force in diabetic patients.At present,Western medical treatment is mainly based on controlling and preventing the progression of the disease,which will result in more obvious amelioration of symptoms in the short term,but the long-term therapeutic effect is still very limited.With the development of traditional Chinese medicine,the advantages of traditional Chinese medicine in the medical field have gradually become prominent,so in recent years,more and more attention has been focused on the pharmacological research of traditional Chinese medicine in the treatment of DPN.By referring to numerous studies and clinical data,it can be found that,in the analysis and induction of TCM in the treatment of DPN,drugs for supplementing Qi(气),promoting blood circulation and removing blood stasis are frequently used.Therefore,this paper selects triple compatible medicinals of Huangqi(Radix Astragalus),Niuxi(Radix Rhizoba)and Jixueteng(Spatholobi)from the existing clinical drug studies to discuss their feasibility,superiority in the treatment of DPN and research progress from the aspect of pharmacology.Starting from the pathogenesis of the disease,the drug compatibility of medicinals is not only committed to relieving the clinical symptoms of patients,but also grasps the fundamental pathogenesis of the disease and treats both the symptoms and root causes of the disease.Yin(阴)deficiency is the basis,blood stasis is the symptom,and both symptoms and root causes are treated.It is not only theoretically feasible,but also widely used in clinical practice,and has achieved good results,providing references for clinical treatment of DPN.
作者
杨青青
张金梅
YANG Qingqing;ZHANG Jinmei
出处
《中医临床研究》
2024年第9期96-100,共5页
Clinical Journal Of Chinese Medicine
关键词
糖尿病周围神经病变
黄芪
牛膝
鸡血藤
角药
Diabetic peripheral neuropathy
Huangqi
Niuxi
Jixueteng Spatholobi
Triple compatible medicinals
