摘要
双酚A(bisphenol A,BPA)作为一种良好的塑料添加剂,在我国的消费量逐年增长。但其也是典型的环境内分泌干扰物,长期暴露于BPA即使低浓度也可对机体产生神经毒性、肝脏毒性、生殖毒性、免疫毒性等多种毒性损害,引发人体发生糖尿病、炎症、肥胖、焦虑抑郁甚至癌症等多种疾病。近些年来,由于工业化发展、塑料垃圾的排放造成对水环境的污染,我国多种环境水体均检测到BPA的存在。且因地理区域、季节温度变化等原因导致各水样BPA暴露水平有所差异。本文介绍了BPA的多种毒性损伤及毒性缓解的主要研究进展,归纳了我国近10年不同环境水体BPA的污染水平并对影响因素进行了分析讨论,以期为BPA的人群暴露剂量与健康风险研究提供参考依据。
The consumption of bisphenol A(BPA)in China has been steadily increasing as a popular plastic additive.However,it is also recognized as a typical environmental endocrine disruptor.Even at low concentrations,prolonged exposure to BPA can lead to neurotoxicity,liver toxicity,reproductive toxicity,immunotoxicity and other adverse effects,contributing to various diseases such as diabetes,inflammation,obesity,anxiety,depression and even cancer.In recent years,BPA has been detected in various environmental water bodies in China due to water pollution caused by industrial development and plastic waste discharge.Furthermore,the level of BPA exposure in each water sample varies depending on geographic regions,seasonal temperature variations,and other factors.This paper presents the latest research advancements in understanding the multiple toxic effects and strategies for mitigating the toxicity of BPA.It also provides a comprehensive summary of BPA pollution levels in various environmental water bodies in China over the past decade,along with an analysis and discussion of influencing factors.The aim is to offer valuable insights for studying population exposure doses and health risks associated with BPA.
作者
王鑫璇
邢文山
李超
刘雅婷
邹丹丹
Wang Xinxuan;Xing Wenshan;Li Chao;Liu Yating;Zou Dandan(Tianjin Key Laboratory of Food Biotechnology,School of Biotechnology and Food Science,Tianjin University of Commerce,Tianjin 300134,China;Tianjin Food Group Co.,Ltd.,Tianjin 300074,China)
出处
《生态毒理学报》
CAS
CSCD
北大核心
2024年第3期208-221,共14页
Asian Journal of Ecotoxicology
基金
天津市自然科学基金青年基金项目(20JCQNJC00850)
天津市大学生创新创业训练项目(202210069127,202310069222)。
关键词
双酚A
毒性
水污染
地表水
生态环境
饮水暴露
BPA
toxicity
water pollution
surface water
ecological environment
drinking water exposure
