摘要
目的:分析甲状腺功能检测与孕期亚临床甲状腺功能减退(SCH)不良妊娠结局的危险因素。方法:回顾性分析2021年3月2日—2022年12月30日就诊于六盘水市水城区人民医院的82例SCH孕产妇的临床资料,根据妊娠结局不同分为不良妊娠组和正常妊娠组。所有孕产妇多次进行甲状腺功能测定,进行单因素、多因素Logistic回归分析,观察不良妊娠影响因素。结果:孕早期、孕中期、孕晚期,不良妊娠组血清促甲状腺激素(TSH)水平高于正常妊娠组,差异有统计学意义(P<0.05);两组血清游离三碘甲状腺原氨酸、血清游离甲状腺素水平比较,差异无统计学意义(P>0.05)。不良妊娠组年龄≥35岁、孕早期TSH≥3.0μIU/mL、孕中期TSH≥3.5μIU/mL、孕晚期TSH≥3.5μIU/mL占比高于正常妊娠组,差异有统计学意义(P<0.05)。回归分析结果显示,年龄≥35岁、孕早期TSH≥3.0μIU/mL、孕中期TSH≥3.5μIU/mL、孕晚期TSH≥3.5μIU/mL为不良妊娠危险因素(P<0.05)。结论:SCH患者甲状腺功能检测结果特征明显,SCH患者不良妊娠与孕早期TSH、孕中期TSH、孕晚期TSH水平密切相关。
Objective:To analyze the risk factors of thyroid function tests and adverse pregnancy outcomes in subclinical hypothyroidism(SCH)during pregnancy.Methods:The clinical data of eighty-two SCH pregnant women who attended Liupanshui Shuicheng District People's Hospital from March 2,2021 to December 30,2022 were retrospectively analyzed and divided into adverse pregnancy and normal pregnancy groups according to the different pregnancy outcomes.All the pregnant women underwent thyroid function measurements several times,and unifactorial and multifactorial logistic regression analyses were performed to observe the factors affecting adverse pregnancy.Results:In early pregnancy,middle pregnancy and late pregnancy,the serum thyroid-stimulating hormone(TSH)level of the adverse pregnancy group was higher than that of the normal pregnancy group,and the difference was statistically significant(P<0.05);comparing the serum free triiodothyronine and serum free thyroxine levels of the two groups,the difference was not statistically significant(P>0.05);the percentage of age≥35 years old,TSH≥3.0μIU/mL in early pregnancy,TSH≥3.5μIU/mL in middle pregnancy,TSH≥3.5μIU/mL in late pregnancy in the adverse pregnancy group was higher than that in the normal pregnancy group,and the difference was statistically significant(P<0.05);regression analysis showed that age≥35 years,TSH≥3.0μIU/mL in early pregnancy,TSH≥3.5μIU/mL in middle pregnancy,TSH≥3.5μIU/mL in late pregnancy were risk factors for adverse pregnancy(P<0.05).Conclusion:The thyroid function test results of SCH patients were characterized significantly,and adverse pregnancy in SCH patients was closely associated with TSH levels in early pregnancy,TSH in middle pregnancy,and TSH in late pregnancy.
作者
肖开粉
刘雍
Xiao Kaifen;Liu Yong(Liupanshui Shuicheng District People's Hospital,Liupanshui 553000,Guizhou Province,China)
出处
《中外医药研究》
2024年第12期55-57,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
孕期亚临床甲状腺功能减退
甲状腺功能
不良妊娠
促甲状腺激素
Subclinical hypothyroidism during pregnancy
Thyroid function
Adverse pregnancy
Thyroid-stimulating hormone
