摘要
目的:探讨养阴舒肝胶囊联合枸橼酸氯米芬治疗多囊卵巢综合征性不孕症的临床效果。方法:选取2019年6月—2022年5月沈阳维康医院收治的72例多囊卵巢综合征性不孕症患者作为研究对象,依据随机数字表法将患者分为对照组和治疗组,各36例。对照组应用枸橼酸氯米芬治疗,治疗组给予养阴舒肝胶囊联合枸橼酸氯米芬治疗。比较两组患者临床疗效,性激素[卵泡刺激素(FSH)、雌二醇(E_(2))、促黄体生成素(LH)、雄性激素(MH)]水平,卵巢血流动力学指标[搏动指数(PI)、阻力指数(RI)],妊娠成功情况。结果:两组患者治疗后,治疗组总有效率高于对照组,差异有统计学意义(P=0.041)。治疗后,两组患者LH、MH水平低于治疗前,FSH、E_(2)水平高于治疗前,且治疗组FSH、LH、E_(2)、MH水平改善情况优于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者PI高于治疗前,RI低于治疗前,且治疗组PI、RI水平改善情况优于对照组,差异有统计学意义(P<0.05)。经过1年随访,治疗组妊娠成功率高于对照组,差异有统计学意义(P=0.009)。结论:养阴舒肝胶囊联合枸橼酸氯米芬治疗多囊卵巢综合征性不孕症患者效果显著,能明显改善患者卵巢功能、激素水平,提高妊娠成功率。
Objective:To investigate the clinical effect of Yangyin Shugan capsule combined with clomiphene citrate on infertility caused by polycystic ovary syndrome.Methods:A total of seventy-two infertility patients with polycystic ovary syndrome admitted to Shenyang Weikang Hospital from June 2019 to May 2022 were selected as the study objects.According to random number table method,the patients were divided into control group and treatment group,with thirty-six cases in each group.The control group was treated with clomiphene citrate,and the treatment group was treated with Yangyin Shugan capsule combined with clomiphene citrate.The clinical efficacy,levels of sex hormones[follicle stimulating hormone(FSH),estradiol(E_(2)),luteinizing hormone(LH),androgen(MH)],ovarian hemodynamic indexes[pulse index(PI),resistance index(RI)]and pregnancy success were compared between the two groups.Results:After treatment,the total effective rate of the treatment group was higher than that of the control group,the difference was statistically significant(P=0.041);after treatment,LH and MH levels in 2 groups were lower than before treatment,FSH and E_(2) levels were higher than before treatment,and the improvement of FSH,LH,E_(2) and MH levels in the treatment group was better than that in the control group,the difference was statistically significant(P<0.05);after treatment,PI was higher than before treatment,RI was lower than before treatment,and the improvement of PI and RI levels in the treatment group was better than that in the control group,with statistical significance(P<0.05);after 1 year follow-up,the success rate of pregnancy in the treatment group was higher than that in the control group,and the difference was statistically significant(P=0.009).Conclusion:Yangyin Shugan capsule combined with clomiphene citrate has remarkable effect in the treatment of infertility patients with polycystic ovary syndrome,which can significantly improve the ovarian function and hormone levels of patients,and increase the success rate of pregnancy.
作者
王延春
Wang Yanchun(Shenyang Weikang Hospital,Shenyang 110066,Liaoning Province,China)
出处
《中外医药研究》
2024年第12期85-87,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
