摘要
目的 探讨7日龄早产儿甲状腺功能的影响因素及其参考值范围,以避免临床上不必要的复查和干预。方法 回顾性分析2020年1月—2023年1月住院的685例早产儿资料。依据胎龄和出生体重分为高危组(胎龄<34周或体重<2 000 g;n=228)与低危组(胎龄≥34周且出生体重≥2 000 g;n=457)。分析甲状腺功能的影响因素,并计算其95%参考值范围。结果 多元线性回归分析显示,胎龄、出生体重、出生季节、性别、辅助生殖等为甲状腺功能的影响因素(P<0.05)。高危组早产儿的游离三碘甲状腺原氨酸(free triiodothyronine,FT3)、游离甲状腺素(free thyroxine,FT4)、总三碘甲状腺原氨酸(total triiodothyronine,TT3)、总甲状腺素(total thyroxine,TT4)、促甲状腺激素(thyroid stimulating hormone,TSH)参考值范围分别为2.79~5.40 pmol/L、8.80~25.64 pmol/L、0.80~2.15 nmol/L、50.06~165.09 nmol/L、0.80~18.57μIU/mL,低危组的分别为3.08~5.93 pmol/L、11.17~26.24pmol/L、1.02~2.27 nmol/L、62.90~168.95 nmol/L、0.69~13.70μIU/mL。FT3、FT4、TT3、TT4与胎龄呈正相关(P<0.05);FT3、FT4、TT3、TT4与出生体重呈正相关(P<0.05),TSH与出生体重呈负相关(P<0.05)。结论 7日龄早产儿甲状腺功能受胎龄、出生体重等因素影响;7日龄早产儿甲状腺功能参考值范围应基于胎龄及出生体重建立。
Objective To investigate the influencing factors and reference ranges for thyroid function in preterm infants at the age of 7 days,with the aim of avoiding unnecessary clinical reexamination and intervention.Methods A retrospective analysis was performed for the data of 685 preterm infants from January 2020 to January 2023.According to gestational age and birth weight,they were divided into a high-risk group(gestational age<34 weeks or birth weight<2000 g;228 infants)and a low-risk group(gestational age≥34 weeks and birth weight≥2000 g;457 infants).The influencing factors for thyroid function were analyzed,and 95%reference range was calculated.Results Gestational age,birth weight,birth season,sex,and assisted reproduction were the influencing factors for thyroid function(P<0.05).For the preterm infants in the high-risk group,the reference ranges of free triiodothyronine(FT3),free thyroxine(FT4),total triiodothyronine(TT3),total thyroxine(TT4),and thyroid stimulating hormone(TSH)were 2.79-5.40 pmol/L,8.80-25.64 pmol/L,0.80-2.15 nmol/L,50.06-165.09 nmol/L,and 0.80-18.57μIU/mL,respectively.For those in the low-risk group,the reference ranges of these indicators were 3.08-5.93 pmol/L,11.17-26.24 pmol/L,1.02-2.27 nmol/L,62.90-168.95 nmol/L,and 0.69-13.70μIU/mL,respectively.FT3,FT4,TT3,and TT4 were positively correlated with gestational age(P<0.05);FT3,FT4,TT3,and TT4 were positively correlated with birth weight(P<0.05);TSH was negatively correlated with birth weight(P<0.05).Conclusions Thyroid function in preterm infants at the age of 7 days is affected by the factors such as gestational age and birth weight,and the reference ranges of thyroid function in preterm infants at the age of 7 days should be established based on gestational age and birth weight.
作者
祁娇
何玺玉
QI Jiao;HE Xi-Yu(Department of Pediatrics,Fifth Medical Center of PLA General Hospital,Beijing 100070,China)
出处
《中国当代儿科杂志》
CAS
CSCD
北大核心
2024年第6期625-630,共6页
Chinese Journal of Contemporary Pediatrics
关键词
甲状腺功能
影响因素
参考值范围
胎龄
早产儿
Thyroid function
Influencing factor
Reference range
Gestational age
Preterm infant