摘要
目的 观察疏肝理气汤联合射频消融(RFA)对晚期肝癌患者预后及肿瘤标志物的影响。方法 收集本院2018年1月至2020年3月期间80例晚期肝癌患者的数据。通过随机对照数字表的方法,我们将这些患者分为观察组和对照组。对照组的40例患者接受RFA治疗,而另外40例患者在对照组基础上联合疏肝理气汤治疗作为观察组。比较两组患者的近期治疗效果,计算总的有效率(objective response rate,ORR)。比较治疗前和治疗1个月后甲胎蛋白(AFP)、糖链抗原199(CA199)和癌胚抗原(CEA)的水平。比较患者3年生存率。统计患者在治疗后并发症。结果 观察组患者治疗后ORR明显要高于对照组患者,存在统计学差异(P=0.033)。观察组患者治疗后CEA, AFP和CA19-9明显低于对照组患者(P<0.05)。两组患者第1年生存率不存在差异(P=0.054)。第2年与第3年对照组患者生存率明显低于观察组患者,存在统计学差异(P=0.026,P=0.020)。观察组患者肝功能衰竭人数要低于对照组患者(P=0.025)。结论 疏肝理气汤联合射频消融可显著改善患者近期疗效,降低肿瘤标志物,增加患者3年生存率,减少肝功能衰竭的发生。
Objective This study assesses the impact of combining Shu Gan Li Qi decoction with radiofrequency ablation(RFA)on the prognosis and biomarkers of advanced liver cancer patients.MethodsData from 80 advanced liver cancer patients treated from January 2018 to March 2020 were analyzed.Patients were randomly assigned to either a control group,receiving only RFA,or an observation group,receiving both RFA and Shu Gan Li Qi decoction,using a randomized control number table approach.We evaluated the immediate effects of the treatments,measured the objective response rate(ORR),and tracked levels of alpha-fetoprotein(AFP),carbohydrate antigen 199(CA199),and carcinoembryonic antigen(CEA)before and one month post-treatment.Additionally,three-year survival rates and post-treatment complications were examined.ResultsPost-treatment,the observation group exhibited a significantly higher ORR than the control group(P=0.033).Furthermore,post-treatment levels of CEA,AFP,and CA19-9 were notably reduced in the observation group compared to the control group(P<0.05).While the one-year survival rates were similar between groups(P=0.054),survival at two and three years was significantly better in the observation group(P=0.026,P=0.020).Incidences of liver failure were also fewer in the observation group(P=0.025).ConclusionThe combination of Shu Gan Li Qi decoction and RFA markedly enhances treatment efficacy in advanced liver cancer,decreases tumor marker levels,improves three-year survival rates,and lowers the occurrence of liver failure.
作者
王鹏
司东晓
余令兵
WANG Peng;SI Dong-xiao;YU Ling-bing(Shangqiu Municipal Hospital,Shangqiu 476000,Henan Province,China)
出处
《罕少疾病杂志》
2024年第6期65-67,共3页
Journal of Rare and Uncommon Diseases
关键词
疏肝理气汤
射频消融
晚期肝癌
预后
肿瘤标志物
Shu Gan Li Qi Decoction
Radiofrequency Ablation
Advanced Liver Cancer
Prognosis
Tumor markers
